安神定志汤治疗抑郁症患者的临床研究

Clinical treatment of depressive patients with anshendingzhi decoction.

作者信息

Yang Jianyu, Jiang Lijuan, Li Yang, Zhu Qingwen, Liu Dong, Xue Wugeng, Cao Bolong, Liu Yingke, Wang Xing

出版信息

J Tradit Chin Med. 2014 Dec;34(6):652-6. doi: 10.1016/s0254-6272(15)30078-9.

DOI:10.1016/s0254-6272(15)30078-9

PMID:25618968

Abstract

OBJECTIVE

To determine the effects of Anshendingzhi decoction (ASDZD) on depression, to compare ASDZD with Danzhixiaoyao pill (DZXYP), and to provide evidence for the clinical treatment of depression with Traditional Chinese Medicine.

METHODS

Seventy-eight patients with depression were enrolled from 2011 to 2013 in this double-blinded study. Patients were randomly divided into two groups: ASDZD (treatment group, n = 39) and DZXYP (control group, n = 39). Hamilton Depressive Scale and TCM Syndrome Differentiation Scale were used to assess depression and efficacy before treatment and 2, 4, and 6 weeks after treatment. The Treatment Emergent Symptoms Scale (TESS) was used to evaluate adverse reactions, observe, and record treatment outcomes.

RESULTS

ASDZD was significantly more effective than DZXYP. There were significant differences between the two groups in terms of recovered patients, overall response rate, and TESS score (all P < 0.05).

CONCLUSION

ASDZD is an effective treatment for depression. ASDZD could improve clinical symptoms and warrants further clinical research and application.

摘要

目的

探讨安神定志汤（ASDZD）对抑郁症的治疗效果，比较其与丹栀逍遥丸（DZXYP）的疗效差异，为中医药治疗抑郁症提供临床依据。

方法

选取2011年至2013年期间的78例抑郁症患者进行双盲研究。将患者随机分为两组：安神定志汤组（治疗组，n = 39）和丹栀逍遥丸组（对照组，n = 39）。采用汉密尔顿抑郁量表和中医证候量表分别在治疗前及治疗后2、4、6周评估抑郁症状及疗效。使用治疗中出现的症状量表（TESS）评估不良反应，观察并记录治疗结果。