Liu Er-Jun, Zhang Wei-Ling, Bai Ya-Ping
Department of TCM, First Hospital Affiliated to Hebei Medical University, Shijiazhuang 050031, China.
Zhongguo Zhen Jiu. 2013 Jun;33(6):497-500.
To observe the differences in the clinical efficacy on depression in comparison among the alliance of acupuncture and Chinese herbal medicine, simple herbal medicine and flupentixol and melitracen tablets.
Two hundred and twenty-seven cases were randomized into a Chinese medicine group(75 cases), an acupuncture + medication group(78 cases) and a western medicine group(74 cases). In the Chinese medicine group, Shugan Jianwei Anshen Decoction was prescribed, in which Radix Bupleuri and Radix Paeoniae Alba were the monarch herbs, one dose a day. In the acupuncture + medication group, on the basic treatment of Chinese medicine, acupuncture was combined every day at Baihui (GV 20), Sishencong (EX-HN 1), Shenmen (HT 7), Lingdao (HT 4), Daling (PC 7), Laogong (PC 8), Yongquan (KI 1), etc. In the western medicine group, deanxit was taken orally, 1 tablet after getting up in the morning and after lunch respectively. The treatment lasted for 8 weeks in the three groups. The change of Hamilton depression scale (HAMD) score and clinical efficacy were observed before and after treatment.
In 8 weeks of treatment, in the acupuncture + medication group, 19 cases were cured, 35 cases were markedly effective, 14 cases were effective and 10 cases failed, the effective rate was 87.2%; in the western medicine group, 11 cases were cured, 32 cases were markedly effective, 18 cases were effective and 13 cases failed, the effective rate was 82.4%; in the Chinese medicine group, 5 cases were cured, 14 cases were markedly effective, 35 cases were effective and 21 cases failed, the effective rate was 72.0%. HAMD assessment was done in 8 weeks of treatment, which was (5.71 +/- 4.32) scores in the acupuncture + medication group, (6.09 +/- 3.78) scores in the western medicine group and (9.24 +/- 3.49) in the Chinese medicine group, the differences were significant in the Chinese medicine group compared with the western medicine group and the acupuncture + medication group (both P < 0.05). The differences in the scores after treatment were not significant statistically between the acupuncture + medication group and the western medicine group (both P > 0.05), but the cured and markedly effective rate in the acupuncture + medication group was superior to that in the western medicine group (P < 0.05).
The alliance of acupuncture and medication achieves the definite efficacy on depression, characterized as less adverse reactions and better safety.
观察针刺与中药联合、单纯中药、氟哌噻吨美利曲辛片治疗抑郁症临床疗效的差异。
将227例患者随机分为中药组（75例）、针药结合组（78例）和西药组（74例）。中药组予疏肝健胃安神汤，以柴胡、白芍为君药，每日1剂。针药结合组在中药基础治疗上，每日加用针刺百会（GV 20）、四神聪（EX-HN 1）、神门（HT 7）、灵道（HT 4）、大陵（PC 7）、劳宫（PC 8）、涌泉（KI 1）等穴位。西药组口服黛力新，晨起及午餐后各服1片。三组均治疗8周，观察治疗前后汉密尔顿抑郁量表（HAMD）评分变化及临床疗效。
治疗8周后，针药结合组治愈19例，显效35例，有效14例，无效10例，有效率为87.2%；西药组治愈11例，显效32例，有效18例，无效13例，有效率为82.4%；中药组治愈5例，显效14例，有效35例，无效21例，有效率为72.0%。治疗8周时进行HAMD评定，针药结合组评分为（5.71±4.32）分，西药组为（6.09±3.78）分，中药组为（9.24±3.49）分，中药组与西药组及针药结合组比较差异均有统计学意义（均P<0.05）。针药结合组与西药组治疗后评分差异无统计学意义（均P>0.05），但针药结合组的治愈率和显效率优于西药组（P<0.05）。
针刺与药物联合治疗抑郁症疗效确切，不良反应少，安全性好。
