氯离子在高血压中隐藏的作用
The hidden hand of chloride in hypertension.
作者信息
McCallum Linsay, Lip Stefanie, Padmanabhan Sandosh
机构信息
BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
出版信息
Pflugers Arch. 2015 Mar;467(3):595-603. doi: 10.1007/s00424-015-1690-8. Epub 2015 Jan 27.
Abstract
Among the environmental factors that affect blood pressure, dietary sodium chloride has been studied the most, and there is general consensus that increased sodium chloride intake increases blood pressure. There is accruing evidence that chloride may have a role in blood pressure regulation which may perhaps be even more important than that of Na(+). Though more than 85 % of Na(+) is consumed as sodium chloride, there is evidence that Na(+) and Cl(-) concentrations do not go necessarily hand in hand since they may originate from different sources. Hence, elucidating the role of Cl(-) as an independent player in blood pressure regulation will have clinical and public health implications in addition to advancing our understanding of electrolyte-mediated blood pressure regulation. In this review, we describe the evidence that support an independent role for Cl(-) on hypertension and cardiovascular health.
摘要
在影响血压的环境因素中，膳食氯化钠的研究最为深入，人们普遍认为氯化钠摄入量增加会导致血压升高。越来越多的证据表明，氯离子可能在血压调节中发挥作用，这一作用可能比钠离子更为重要。尽管超过85%的钠离子是以氯化钠的形式摄入，但有证据表明，钠离子和氯离子的浓度不一定同步变化，因为它们可能来自不同的来源。因此，阐明氯离子作为血压调节中独立因素的作用，除了能增进我们对电解质介导的血压调节的理解外，还将具有临床和公共卫生意义。在本综述中，我们描述了支持氯离子在高血压和心血管健康方面具有独立作用的证据。
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