University of Groningen, University Medical Center Groningen, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, The Netherlands; University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.
Allergy. 2015 Apr;70(4):461-4. doi: 10.1111/all.12569. Epub 2015 Jan 26.
The aim of this study was to assess the genetic association of Filaggrin loss-of-function (FLG LOF) genetic variants with food allergy, and to investigate the added value of this test in diagnosing food allergy. Clinical reactivity to foods was diagnosed by the gold standard, the double-blind, placebo-controlled food challenge. Of 155 children, 33 (21.3%) children had at least one FLG LOF variant, and of these, 29 (87.9%) were clinically reactive to at least one food, compared to 73 of 122 children (59.8%) carrying wild-type alleles. The odds ratio for having at least one FLG LOF variant and clinical reactivity to at least one food was 4.9 (CI = 1.6-14.7, P = 0.005), corresponding to a relative risk of 1.5, compared to carriers of wild-type alleles. Prediction of food allergy improved when FLG LOF variants were included in the model. Therefore, genetic markers may be useful as an addition to clinical assessment in the diagnosis of food allergy.
本研究旨在评估丝聚蛋白无功能（FLG LOF）基因突变与食物过敏的遗传关联，并探讨该检测在食物过敏诊断中的附加价值。通过金标准——双盲、安慰剂对照食物挑战来诊断临床食物过敏反应。在 155 名儿童中，33 名（21.3%）儿童至少携带一种 FLG LOF 变异，其中 29 名（87.9%）对至少一种食物有临床反应，而携带野生型等位基因的 122 名儿童中，有 73 名（59.8%）有临床反应。至少携带一种 FLG LOF 变异且对至少一种食物有临床反应的比值比为 4.9（CI=1.6-14.7，P=0.005），与携带野生型等位基因的儿童相比，风险比为 1.5。当将 FLG LOF 变异纳入模型时，食物过敏的预测得到改善。因此，遗传标志物可能有助于补充临床评估，以诊断食物过敏。
