Czyzewska-Szafran H, Wutkiewicz M, Remiszewska M, Jastrzebski Z, Czarnecki A, Danysz A
Department of Pharmacology, Institute of Drug Research and Control, Warszawa, Poland.
Pol J Pharmacol Pharm. 1989 Nov-Dec;41(6):619-27.
The relevance of GABA-ergic system in hypertensive state has been studied. GABA content, GAD activity and GABA-A receptor binding in various brain areas in age-matched spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto rats (WKY) was compared. Out of 9 brain areas studied the GABA content was significantly lower in the substantia nigra, hypothalamus, hypothalamus posterior and hippocampus of SHR rats. GAD activity was lowered in the hypothalamus and hippocampus of young SHR and adult SHR rats (4, 8, 14 weeks old). Scatchard analysis of the binding isotherms indicated a lower Bmax of the binding sites in the hypothalamus and hippocampus of 8 and 14 weeks old SHR rats. These results suggest that activity of GABA-ergic system differs substantially in SHR and WKY rats brain. Furthermore, these differences appear already in young prehypertensive SHR rats as well as in the early stages of hypertension.
已对γ-氨基丁酸（GABA）能系统在高血压状态下的相关性进行了研究。比较了年龄匹配的自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto大鼠（WKY）不同脑区中的GABA含量、谷氨酸脱羧酶（GAD）活性和GABA-A受体结合情况。在所研究的9个脑区中，SHR大鼠黑质、下丘脑、下丘脑后部和海马体中的GABA含量显著降低。年轻SHR大鼠和成年SHR大鼠（4周、8周、14周龄）下丘脑和海马体中的GAD活性降低。对结合等温线的Scatchard分析表明，8周龄和14周龄SHR大鼠下丘脑和海马体中结合位点的最大结合容量（Bmax）较低。这些结果表明，SHR大鼠和WKY大鼠脑中GABA能系统的活性存在显著差异。此外，这些差异在年轻的高血压前期SHR大鼠以及高血压早期阶段就已出现。
