Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Nat Immunol. 2015 Mar;16(3):306-17. doi: 10.1038/ni.3094. Epub 2015 Jan 26.
The recognized diversity of innate lymphoid cells (ILCs) is rapidly expanding. Three ILC classes have emerged, ILC1, ILC2 and ILC3, with ILC1 and ILC3 including several subsets. The classification of some subsets is unclear, and it remains controversial whether natural killer (NK) cells and ILC1 cells are distinct cell types. To address these issues, we analyzed gene expression in ILCs and NK cells from mouse small intestine, spleen and liver, as part of the Immunological Genome Project. The results showed unique gene-expression patterns for some ILCs and overlapping patterns for ILC1 cells and NK cells, whereas other ILC subsets remained indistinguishable. We identified a transcriptional program shared by small intestine ILCs and a core ILC signature. We revealed and discuss transcripts that suggest previously unknown functions and developmental paths for ILCs.
先天淋巴细胞（ILCs）的公认多样性正在迅速扩大。已经出现了三类 ILC，即 ILC1、ILC2 和 ILC3，其中 ILC1 和 ILC3 包括几个亚群。一些亚群的分类尚不清楚，NK 细胞和 ILC1 细胞是否为不同的细胞类型仍存在争议。为了解决这些问题，我们作为免疫基因组计划的一部分，分析了从小肠、脾脏和肝脏分离的 ILCs 和 NK 细胞的基因表达。结果表明，一些 ILC 具有独特的基因表达模式，而 ILC1 细胞和 NK 细胞的表达模式则存在重叠，而其他 ILC 亚群则仍然难以区分。我们确定了一个由小肠 ILCs 共享的转录程序和一个核心 ILC 特征。我们揭示并讨论了提示 ILCs 以前未知的功能和发育途径的转录本。
Zotero 插件
