Polymers and Composites Division, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences , Zhongguan West Road 1219, Zhenhai District, Ningbo, Zhejiang 315201, P.R. China.
ACS Appl Mater Interfaces. 2015 Feb 11;7(5):3003-8. doi: 10.1021/acsami.5b00184. Epub 2015 Jan 28.
An interpenetrating network (IPN) strategy has been widely facilitated to construct strong and tough hydrogels, but most of the efforts have been focused on organic/organic networks. Herein, aqueous dispersible 2,2'-(ethylenedioxy)-diethanethiol (EDDET) cross-linked graphene oxide (E-cGO) skeleton was in situ incorporated into a PVA matrix, resulting in novel inorganic/organic IPN hydrogels with super mechanical and chondrocyte cell-adhesion properties. The unique interpenetrating structure and hydrogen bonding were demonstrated to play critical roles in enhancing the compressive property of the IPN hydrogels, in comparison to the GO and thermally reduced graphene oxide (T-rGO) filled hydrogels. It is critical that the E-cGO/PVA hydrogels have been demonstrated as being biocompatible, which make the E-cGO/PVA hydrogels promising candidate biomaterials for load-bearing biotissue substitution.
互穿网络（IPN）策略已被广泛应用于构建强韧水凝胶，但大多数研究都集中在有机/有机网络上。在此，我们将可分散在水溶液中的 2,2'-(乙二氧基)二乙硫醇（EDDET）交联氧化石墨烯（E-cGO）骨架原位掺入 PVA 基质中，制备出具有超机械性能和软骨细胞黏附性能的新型无机/有机 IPN 水凝胶。独特的互穿结构和氢键被证明对提高 IPN 水凝胶的压缩性能起着关键作用，与 GO 和热还原氧化石墨烯（T-rGO）填充水凝胶相比更是如此。重要的是，E-cGO/PVA 水凝胶已被证明具有生物相容性，这使得 E-cGO/PVA 水凝胶成为有希望的用于承重生物组织替代的生物材料。
