Tabachnick J, Perlish J S, Freed R M, Chang L F
Albert Einstein Medical Center, Philadelphia, PA, USA.
J Invest Dermatol. 1966 Jun;46(6):555-60. doi: 10.1038/jid.1966.85.
An increase in extracellular epidermal DNase I occurs after slight to severe trauma to skin and appears to be generally associated with an inflammatory response including epidermal cell proliferation, rather than cell death. It precedes or accompanies the epidermal hyperplasia which occurs during healing of superficial wounds and regrowth of hair. It is suggested that extracellular epidermal DNase I is primarily of humoral origin and its increase after skin trauma results from increased vascular permeability and diffusion of a DNase I-inhibitor complex into the epidermis where the inhibitor is ultimately inactivated or destroyed.
皮肤受到轻微至严重创伤后，细胞外表皮脱氧核糖核酸酶I（DNase I）会增加，且似乎通常与包括表皮细胞增殖在内的炎症反应相关，而非细胞死亡。它在浅表伤口愈合和毛发再生过程中发生的表皮增生之前出现或与之伴随。有人提出，细胞外表皮DNase I主要源自体液，皮肤创伤后其增加是由于血管通透性增加以及一种DNase I-抑制剂复合物扩散到表皮，在表皮中该抑制剂最终被灭活或破坏。
