Zhang Lu, Duan Liping, Liu Yixuan, Leng Yuxin, Zhang Hua, Liu Zuojing, Wang Kun
Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China. Email:
Zhonghua Nei Ke Za Zhi. 2014 Dec;53(12):969-75.
To estimate the prevalence and risk factors for irritable bowel syndrome (IBS) in China.
Cross-sectional studies relevant to IBS conducted among Chinese were identified through the databases including PubMed, Web of Science, the Cochrane Library, CBM, CNKI, Wanfang data and VIP. Quality of studies was assessed according to the criteria for cross-sectional studies recommended by Agency for Healthcare Research and Quality (AHRQ). Analysis of data, publication bias and sensitivity were performed with Stata (Version 12.0).
A total of twenty-three studies were extracted. No obvious publication bias was detected in all analysis except the effect of depression on IBS prevalence. Pooled prevalence of IBS in China was 6.5%. IBS was more common in women than in men (8.1% vs 6.8%;OR = 1.23, 95%CI 1.09-1.38) and high rate in age group between 30 to 59 years (6.9%; OR = 1.22, 95%CI 1.12-1.32) . Intestinal infection history (OR = 2.39, 95%CI 1.69-3.38), anxiety (OR = 2.95, 95%CI 1.94-4.49), depression (OR = 1.85, 95%CI 1.11-3.09), food allergy (OR = 2.80, 95%CI 2.12-3.67) and alcohol consumption (OR = 1.15, 95%CI 1.07-1.24) might increase the risk for IBS. There were no significant difference of IBS prevalence between urban and rural areas (OR = 0.97, 95%CI 0.72-1.29) , neither in different education classes (OR = 0.85, 95%CI 0.70-1.03) . Sub-group analysis showed IBS prevalence varied apparently with different diagnostic criteria: prevalence defined by Manning was 11.8% and by RomeIIand Rome III prevalence values were 4.4% and 8.9% respectively.
Pooled prevalence of IBS in China was 6.5%. IBS is more common in age group between 30 to 59 years. Female, history of intestinal infection, anxiety, depression, food allergy and alcohol consumption were risk factors for IBS in Chinese population.
评估中国肠易激综合征（IBS）的患病率及危险因素。
通过PubMed、Web of Science、Cochrane图书馆、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方数据和维普资讯等数据库，检索在中国进行的与IBS相关的横断面研究。根据美国医疗保健研究与质量局（AHRQ）推荐的横断面研究标准评估研究质量。使用Stata（12.0版）进行数据分析、发表偏倚分析和敏感性分析。
共提取了23项研究。除抑郁对IBS患病率的影响外，所有分析均未检测到明显的发表偏倚。中国IBS的合并患病率为6.5%。IBS在女性中比男性更常见（8.1%对6.8%；OR = 1.23，95%CI 1.09 - 1.38），在30至59岁年龄组中患病率较高（6.9%；OR = 1.22，95%CI 1.12 - 1.32）。肠道感染史（OR = 2.39，95%CI 1.69 - 3.38）、焦虑（OR = 2.95，95%CI 1.94 - 4.49）、抑郁（OR = 1.85，95%CI 1.11 - 3.09）、食物过敏（OR = 2.80，95%CI 2.12 - 3.67）和饮酒（OR = 1.15，95%CI 1.07 - 1.24）可能增加IBS的风险。城乡地区IBS患病率无显著差异（OR = 0.97，95%CI 0.72 - 1.29），不同教育程度组之间也无显著差异（OR = 0.85，95%CI 0.70 - 1.03）。亚组分析显示，IBS患病率因诊断标准不同而有明显差异：Manning标准定义的患病率为11.8%，Rome II和Rome III标准定义的值分别为4.4%和8.9%。
中国IBS的合并患病率为6.5%。IBS在30至59岁年龄组中更常见。女性、肠道感染史、焦虑、抑郁、食物过敏和饮酒是中国人群IBS的危险因素。
