类风湿性关节炎。Rsk2 在增生性疾病中的双重作用。
Rheumatoid arthritis. The two faces of Rsk2 in hyperplastic disease.
机构信息
Rheumatology Research Group, Centre for Translational Inflammation Research, School of Immunity &Infection, College of Medical &Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, UK.
出版信息
Nat Rev Rheumatol. 2015 Apr;11(4):203-5. doi: 10.1038/nrrheum.2015.1. Epub 2015 Jan 27.
Given the established role of 90 kDa ribosomal S6 kinases (Rsk) in oncogenesis, and the promise of new Rsk-blocking cancer treatments, it is perhaps surprising that Rsk2-mediated inhibition of hyperplasia has now been demonstrated to occur in the arthritic synovium. Does this functional duality make Rsk2 a risky target for the treatment of rheumatoid arthritis?
鉴于 90 kDa 核糖体 S6 激酶（Rsk）在肿瘤发生中的既定作用，以及新的 Rsk 阻断癌症治疗的前景，现在已经证明 Rsk2 介导的增生抑制发生在关节炎滑膜中，这也许令人惊讶。这种功能双重性是否使 Rsk2 成为治疗类风湿关节炎的高风险靶点？
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