Javanmard Shaghayegh Haghjooy, Shahsavarzadeh Tayebeh, Saadatnia Mohammad
Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Hezar Jerib Avenue, Isfahan, Iran.
Department of Neurology, Isfahan Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2015 Jan 6;4:6. doi: 10.4103/2277-9175.148287. eCollection 2015.
Decreased concentration of tissue factor pathway inhibitor (TFPI) is a risk factor for development of deep venous thrombosis and coronary heart disease, but there is no evidence for the relationship between TFPI and cerebral venous and sinus thrombosis (CVST). The aim of this study was to determine the level of TFPI in healthy population and in patients with CVST.
We determined the plasma level of TFPI in 20 patients with CVST (cases) and 31 healthy volunteer subjects (as control group) by enzyme linked immunoassay method. We also examined the association between TFPI and the risk of CVST. Continuous variables were compared between groups using Student's t test, and odds ratio was calculated by multiple logistic regression analysis.
The mean TFPI was significantly lower in the CVST group compared with the control group (8.60 ± 4.05 ng/mL; 14.6 ± 8.6 ng/mL; P = 0. 005), respectively. The odds ratio for CVST associated with low (<25(th) percentile) levels of TFPI was 5.429 (95% CI, 1.487-19.82, P = 0.012).
Our investigation demonstrates that reduced TFPI may be one of the risk factors of CVST and associated with increasing the risk of developing CVST.
组织因子途径抑制物（TFPI）浓度降低是深静脉血栓形成和冠心病发生的危险因素，但尚无证据表明TFPI与脑静脉窦血栓形成（CVST）之间存在关联。本研究旨在测定健康人群和CVST患者的TFPI水平。
我们采用酶联免疫吸附测定法测定了20例CVST患者（病例组）和31名健康志愿者（作为对照组）的血浆TFPI水平。我们还研究了TFPI与CVST风险之间的关联。使用Student t检验比较组间的连续变量，并通过多元逻辑回归分析计算比值比。
CVST组的平均TFPI水平显著低于对照组（分别为8.60±4.05 ng/mL；14.6±8.6 ng/mL；P = 0.005）。TFPI水平低（<第25百分位数）与CVST相关的比值比为5.429（95%可信区间，1.487 - 19.82，P = 0.012）。
我们的研究表明，TFPI降低可能是CVST的危险因素之一，并与CVST发生风险增加相关。
