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本文引用的文献

1
MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae.MapZ标记肺炎链球菌中的分裂位点并定位FtsZ环。
Nature. 2014 Dec 11;516(7530):259-262. doi: 10.1038/nature13966. Epub 2014 Nov 26.
2
Cross-phosphorylation of bacterial serine/threonine and tyrosine protein kinases on key regulatory residues.细菌丝氨酸/苏氨酸和酪氨酸蛋白激酶在关键调节残基上的交叉磷酸化。
Front Microbiol. 2014 Sep 17;5:495. doi: 10.3389/fmicb.2014.00495. eCollection 2014.
3
Agents of change - concepts in Mycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling.变化因子——结核分枝杆菌丝氨酸/苏氨酸/酪氨酸磷酸信号传导中的概念
Mol Microbiol. 2014 Oct;94(2):231-41. doi: 10.1111/mmi.12747. Epub 2014 Aug 25.
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Pbp2x localizes separately from Pbp2b and other peptidoglycan synthesis proteins during later stages of cell division of Streptococcus pneumoniae D39.在肺炎链球菌D39细胞分裂后期，Pbp2x与Pbp2b及其他肽聚糖合成蛋白分开定位。
Mol Microbiol. 2014 Oct;94(1):21-40. doi: 10.1111/mmi.12745. Epub 2014 Aug 21.
5
PrkC-mediated phosphorylation of overexpressed YvcK protein regulates PBP1 protein localization in Bacillus subtilis mreB mutant cells.PrkC介导的过表达YvcK蛋白磷酸化作用调节枯草芽孢杆菌mreB突变体细胞中PBP1蛋白的定位。
J Biol Chem. 2014 Aug 22;289(34):23662-9. doi: 10.1074/jbc.M114.562496. Epub 2014 Jul 10.
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Serine/threonine protein phosphatase-mediated control of the peptidoglycan cross-linking L,D-transpeptidase pathway in Enterococcus faecium.丝氨酸/苏氨酸蛋白磷酸酶介导的粪肠球菌肽聚糖交联L,D-转肽酶途径的调控
mBio. 2014 Jul 8;5(4):e01446-14. doi: 10.1128/mBio.01446-14.
7
Proteome and phosphoproteome analysis of the serine/threonine protein kinase E mutant of Mycobacterium tuberculosis.结核分枝杆菌丝氨酸/苏氨酸蛋白激酶 E 突变体的蛋白质组和磷酸化蛋白质组分析。
Life Sci. 2014 Jul 30;109(2):116-26. doi: 10.1016/j.lfs.2014.06.013. Epub 2014 Jun 24.
8
Biochemical and spatial coincidence in the provisional Ser/Thr protein kinase interaction network of Mycobacterium tuberculosis.结核分枝杆菌丝氨酸/苏氨酸蛋白激酶互作网络的暂态生物化学和空间吻合性。
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9
Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to β-lactam antibiotics.对一种PASTA激酶的选择性药理抑制会增加单核细胞增生李斯特菌对β-内酰胺类抗生素的敏感性。
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10
HupB, a nucleoid-associated protein of Mycobacterium tuberculosis, is modified by serine/threonine protein kinases in vivo.结核分枝杆菌核衣壳相关蛋白 HupB 可在体内被丝氨酸/苏氨酸蛋白激酶修饰。
J Bacteriol. 2014 Jul;196(14):2646-57. doi: 10.1128/JB.01625-14. Epub 2014 May 9.

丝氨酸/苏氨酸磷酸化作为细菌中的一种调控机制。

Ser/Thr phosphorylation as a regulatory mechanism in bacteria.

作者信息

Dworkin Jonathan

机构信息

Department of Microbiology & Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

出版信息

Curr Opin Microbiol. 2015 Apr;24:47-52. doi: 10.1016/j.mib.2015.01.005. Epub 2015 Jan 24.

DOI:10.1016/j.mib.2015.01.005
PMID:25625314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4380854/
Abstract

This review will discuss some recent work describing the role of Ser/Thr phosphorylation as a post-translational mechanism of regulation in bacteria. I will discuss the interaction between bacterial eukaryotic-like Ser/Thr kinases (eSTKs) and two-component systems as well as hints as to physiological function of eSTKs and their cognate eukaryotic-like phosphatases (eSTPs). In particular, I will highlight the role of eSTKs and eSTPs in the regulation of peptidoglycan metabolism and protein synthesis. In addition, I will discuss how data from phosphoproteomic surveys suggest that Ser/Thr phosphorylation plays a much more significant physiological role than would be predicted simply based on in vivo and in vitro analyses of individual kinases.

摘要

本综述将讨论一些近期的研究工作，这些工作描述了丝氨酸/苏氨酸磷酸化作为细菌中一种翻译后调控机制的作用。我将讨论细菌类真核丝氨酸/苏氨酸激酶（eSTK）与双组分系统之间的相互作用，以及关于eSTK及其同源类真核磷酸酶（eSTP）生理功能的线索。特别地，我将强调eSTK和eSTP在肽聚糖代谢和蛋白质合成调控中的作用。此外，我将讨论磷酸化蛋白质组学调查的数据如何表明，丝氨酸/苏氨酸磷酸化所起的生理作用比仅基于对单个激酶的体内和体外分析所预测的要重要得多。