牙周病与年龄相关性黄斑变性：来自第三次全国健康与营养检查调查的结果

PERIODONTAL DISEASE AND AGE-RELATED MACULAR DEGENERATION: Results From the National Health and Nutrition Examination Survey III.

作者信息

Wagley Sushant, Marra Kyle V, Salhi Rama A, Gautam Shiva, Campo Rafael, Veale Peter, Veale John, Arroyo Jorge G

机构信息

*College of Human Medicine, Michigan State University, East Lansing, Michigan; †Division of Ophthalmology, Beth Israel Deaconess Medical Center, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; ‡Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts; and §Veale and Veale Dentistry, Dartmouth, Massachusetts.

出版信息

Retina. 2015 May;35(5):982-8. doi: 10.1097/IAE.0000000000000427.

DOI:10.1097/IAE.0000000000000427

PMID:25627087

Abstract

PURPOSE

To study the association between periodontal disease (PD) and age-related macular degeneration (AMD).

METHODS

For this cross-sectional analysis, 8,208 adults aged 40 years or older with retinal photographs graded for AMD were used from the National Health and Nutrition Examination Survey III. National Health and Nutrition Examination Survey III standardized dental measurements of PD status (defined as loss of >3 mm of attachment between the gum and tooth in at least 10% of sites measured). Participants were stratified into 60 years or younger and older than 60 years of age groups. Association between PD and AMD was assessed while controlling for sex, race, education, poverty income ratio, smoking, hypertension, body mass index, cardiovascular disease, and C-reactive protein.

RESULTS

In this population, a total of 52.30% had PD, and the prevalence of AMD was 11.45%. Logistic regression model controlled for confounders and stratified by age 60 years or younger versus older than 60 years showed PD to be independently associated with an increased risk for AMD (odds ratio = 1.96, 95% confidence interval = 1.22-3.14, P = 0.006) for those aged 60 years or younger but not for subjects older than 60 years (odds ratio = 1.32, confidence interval = 0.93-1.90, P = 0.120).

CONCLUSION

In this population-based study, PD is independently associated with AMD in those aged 60 years or younger.

摘要

目的

研究牙周疾病（PD）与年龄相关性黄斑变性（AMD）之间的关联。

方法

在本次横断面分析中，使用了来自第三次国家健康与营养检查调查的8208名40岁及以上成年人，这些人的视网膜照片已根据AMD进行分级。第三次国家健康与营养检查调查对PD状况进行了标准化牙科测量（定义为在至少10%的测量部位牙龈与牙齿之间的附着丧失>3毫米）。参与者被分为60岁及以下和60岁以上年龄组。在控制性别、种族、教育程度、贫困收入比、吸烟、高血压、体重指数、心血管疾病和C反应蛋白的同时，评估PD与AMD之间的关联。

结果

在该人群中，共有52.30%患有PD，AMD的患病率为11.45%。对混杂因素进行控制并按60岁及以下与60岁以上年龄分层的逻辑回归模型显示，对于60岁及以下的人群，PD与AMD风险增加独立相关（比值比=1.96，95%置信区间=1.22 - 3.14，P = 0.006），而对于60岁以上的受试者则不然（比值比=1.32，置信区间=0.93 - 1.90，P = 0.120）。