de la Sierra A, Villalta J, Lozano M, Campa M T, Ingelmo M
An Med Interna. 1989 Sep;6(9):481-2.
A case of a 59-year-old female suffering from immunohemolytic anemia, coombs negative, is presented. Six years after the diagnosis, this patient developed an adenocarcinoma of the gallbladder, with invasion of lymph nodes, liver and peritoneum; at this moment the coombs, test proving positive. The possible pathogenetic mechanisms are discussed, despite the rareness of this delayed association which is probably the first described in literature.
本文报告一例59岁女性免疫性溶血性贫血患者,抗人球蛋白试验阴性。诊断6年后,该患者发生胆囊腺癌,伴有淋巴结、肝脏及腹膜侵犯;此时抗人球蛋白试验结果呈阳性。尽管这种延迟关联罕见且可能是文献中首次描述,但仍对其可能的发病机制进行了讨论。