Oliveira Douglas Guimaraes de, Toneloto Maria Gabriela Cavicchia, Moreira Marcos Mello, Bustorff-Silva Joaquim Murray, Souza Gabriel Franco de, Martins Luiz Claudio, Kosour Carolina, Dragosavac Desanka, Falcão Antonio Luis Eiras
Faculty of Medical Sciences, State University of Campinas, Brazil.
Department of Physical Therapy, University of Jaguariuna, Brazil.
Acta Cir Bras. 2015 Jan;30(1):1-5. doi: 10.1590/S0102-86502015001000001.
To investigate the hemodynamic and ventilatory changes associated with the creation of an experimental bronchopleural fistula (BPF) treated by mechanical ventilation and thoracic drainage with or without a water seal.
Six large white pigs weighing 25 kg each which, after general anesthesia, underwent endotracheal intubation (6mm), and mechanically ventilation. Through a left thoracotomy, a resection of the lingula was performed in order to create a BPF with an output exceeding 50% of the inspired volume. The chest cavity was closed and drained into the water sealed system for initial observation of the high output BPF.
Significant reduction in BPF output and PaCO2 was related after insertion of a water-sealed thoracic drain, p< 0.05.
Insertion of a water-sealed thoracic drain resulted in reduction in bronchopleural fistula output and better CO2 clearance without any drop in cardiac output or significant changes in mean arterial pressure.
研究在机械通气和胸腔引流（有无水封）治疗实验性支气管胸膜瘘（BPF）过程中相关的血流动力学和通气变化。
选用6只体重均为25千克的大型白色猪，全身麻醉后进行气管插管（6毫米）并机械通气。通过左胸切口切除舌叶，以建立一个输出量超过吸入气量50%的BPF。关闭胸腔并引流至水封系统，对高输出量BPF进行初步观察。
插入水封胸腔引流管后，BPF输出量和动脉血二氧化碳分压（PaCO2）显著降低，p<0.05。
插入水封胸腔引流管可降低支气管胸膜瘘的输出量，并改善二氧化碳清除，而心输出量无下降，平均动脉压也无显著变化。
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