WW 蛋白的酪氨酸磷酸化
Tyrosine phosphorylation of WW proteins.
作者信息
Reuven Nina, Shanzer Matan, Shaul Yosef
机构信息
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
出版信息
Exp Biol Med (Maywood). 2015 Mar;240(3):375-82. doi: 10.1177/1535370214565991. Epub 2015 Jan 26.
Abstract
A number of key regulatory proteins contain one or two copies of the WW domain known to mediate protein-protein interaction via proline-rich motifs, such as PPxY. The Hippo pathway components take advantage of this module to transduce tumor suppressor signaling. It is becoming evident that tyrosine phosphorylation is a critical regulator of the WW proteins. Here, we review the current knowledge on the involved tyrosine kinases and their roles in regulating the WW proteins.
摘要
许多关键调控蛋白含有一个或两个WW结构域拷贝，已知该结构域可通过富含脯氨酸的基序（如PPxY）介导蛋白质-蛋白质相互作用。Hippo信号通路组分利用这一模块来传导肿瘤抑制信号。越来越明显的是，酪氨酸磷酸化是WW蛋白的关键调节因子。在此，我们综述了目前关于相关酪氨酸激酶及其在调节WW蛋白中的作用的知识。
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