Jortner B S, Shell L, el-Fawal H, Ehrich M
Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061.
Neurotoxicology. 1989 Winter;10(4):717-26.
Chickens which developed organophosphorus ester-induced delayed neuropathy (OPIDN) due to a single oral dose of 360 mg/kg tri-ortho-tolyl phosphate were followed for up to 64 days following toxicant administration. Neuropathy was well developed by day 14. Progressive, marked but incomplete clinical improvement was observed between that time and day 49, associated with regenerative process was initially noted on day 16 at a distal, non-terminal level of the tibial nerve branch to the lateral head of the gastrocnemius muscle. One or more axonal sprouts were seen in bands of Büngner, but only one regenerated fiber per band myelinated and grew. By day 64 the nerves from treated hens closely resembled those from the controls. Myelinated nerve fiber degeneration was noted in distal regions of long spinal cord white matter tracts, but no subsequent regeneration was observed in this region. These studies indicate that in OPIDN there is a transient period of neuronal injury, and that damaged cells having peripherally directed neurites are likely able to undertake axonal regeneration.
给鸡单次口服360毫克/千克磷酸三邻甲苯酯后，对出现有机磷酸酯诱导的迟发性神经病（OPIDN）的鸡在给予毒物后长达64天进行跟踪观察。到第14天时，神经病已充分发展。在那时至第49天期间观察到渐进性、明显但不完全的临床改善，与再生过程相关，最初在第16天在腓肠肌外侧头的胫神经分支的远端、非终末水平处注意到再生过程。在Büngner带中可见一个或多个轴突发芽，但每条带只有一根再生纤维髓鞘化并生长。到第64天时，处理过的母鸡的神经与对照母鸡的神经非常相似。在长脊髓白质束的远端区域注意到有髓神经纤维变性，但在该区域未观察到随后的再生。这些研究表明，在OPIDN中存在神经元损伤的短暂时期，并且具有向外周延伸神经突的受损细胞可能能够进行轴突再生。
