Kong-González Monserrat, Pérez-Cortéz Jesús Giovanni, Hernández-Girón Carlos, Macías-Morales Nayeli, Flores-Aldana Mario
Escuela de Nutrición, Campus Universitario Siglo XXI, Toluca, Estado de México, México. Address: Av. Universidad N° 655, CP 62100, Cuernavaca, Morelos, México. Email:
Campus de la Salud, Universidad Latinoamericana, Cuernavaca, Morelos, México.
Medwave. 2015 Jan 7;15(1):e6062. doi: 10.5867/medwave.2015.01.6062.
Fatty acids have an important role in structure and function of the nervous system. Recently, epidemiologic studies on neurodegenerative disorders have evaluated the usefulness of polyunsaturated fatty acids on multiple sclerosis.
To examine recent studies, clinical trials, and reviews on the therapeutic effect of polyunsaturated fatty acids in multiple sclerosis.
We conducted a search in MEDLINE/PubMed and Cochrane Library with the terms "fatty acids", "omega-3" and "omega-6" in combination with "multiple sclerosis". Articles were selected according to their relevance on the topic.
Epidemiologic studies have shown benefits of dietary supplementation with polyunsaturated fatty acids--especially omega-3--in relation to inflammatory, autoimmune and neurodegenerative disorders. In contrast, the studies do not show a beneficial effect of polyunsaturated fatty acids in multiple sclerosis. However, there are limitations related to design and sample issues in these studies.
There is some evidence of a protective effect of polyunsaturated fatty acids on the risk of multiple sclerosis. Despite this, to date controlled trials have not produced definite results on the benefits of supplementation with polyunsaturated fatty acids in patients with multiple sclerosis. Any potential benefit will have to be confirmed in the long term.
脂肪酸在神经系统的结构和功能中起着重要作用。最近，关于神经退行性疾病的流行病学研究评估了多不饱和脂肪酸对多发性硬化症的作用。
探讨近期关于多不饱和脂肪酸治疗多发性硬化症疗效的研究、临床试验及综述。
我们在MEDLINE/PubMed和Cochrane图书馆中以“脂肪酸”“ω-3”“ω-6”与“多发性硬化症”组合进行检索。根据文章与该主题的相关性进行筛选。
流行病学研究表明，饮食中补充多不饱和脂肪酸，尤其是ω-3，对炎症、自身免疫和神经退行性疾病有益。相比之下，这些研究未显示多不饱和脂肪酸对多发性硬化症有有益作用。然而，这些研究在设计和样本问题方面存在局限性。
有一些证据表明多不饱和脂肪酸对多发性硬化症风险有保护作用。尽管如此，迄今为止的对照试验尚未就补充多不饱和脂肪酸对多发性硬化症患者的益处得出明确结果。任何潜在益处都必须经过长期确认。
