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范可尼贫血女性患者的拔牙处理

Management of dental extraction in a female patient with fanconi anemia.

作者信息

Peisker Andre, Raschke Gregor Franziskus, Guentsch Arndt, Roshanghias Korosh, Schultze-Mosgau Stefan

机构信息

Department of Cranio-Maxillofacial & Plastic Surgery, Jena University Hospital, Jena, Germany.

Center of Dental Medicine, Jena University Hospital, Jena, Germany ; Department of Surgical Sciences, Marquette University, School of Dentistry, Milwaukee, Wisconsin, USA.

出版信息

J Dent (Tehran). 2014 Sep;11(5):613-9. Epub 2014 Sep 30.

PMID:25628690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4290783/
Abstract

Oral surgery in patients with bleeding disorders is associated with a high risk of bleeding during and after surgery. This article is aimed to present the case of an eight-year-old girl suffering from severe Fanconi anemia with pancytopenia who underwent a dental extraction. The hemostatic effect of local administration of tranexamic acid in combination with a primary suture seems to be extremely helpful in order to reduce the necessity of blood products and the risk of postoperative bleeding.

摘要

出血性疾病患者的口腔外科手术与手术期间及术后的高出血风险相关。本文旨在介绍一名患有严重范可尼贫血伴全血细胞减少症的8岁女孩接受拔牙手术的病例。局部应用氨甲环酸联合一期缝合的止血效果似乎对减少血制品的使用需求和术后出血风险非常有帮助。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/5b36d4d73d88/jod-11-613f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/3c4ce2679337/jod-11-613f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/f864ded9160a/jod-11-613f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/bdf902cd30d6/jod-11-613f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/b491d5dc58e5/jod-11-613f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/5b36d4d73d88/jod-11-613f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/3c4ce2679337/jod-11-613f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/f864ded9160a/jod-11-613f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/bdf902cd30d6/jod-11-613f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/b491d5dc58e5/jod-11-613f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e91/4290783/5b36d4d73d88/jod-11-613f5.jpg

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本文引用的文献

1
Dental management of hemophiliac child under general anesthesia.全身麻醉下血友病患儿的牙科治疗管理
J Indian Soc Pedod Prev Dent. 2011 Jan-Mar;29(1):74-9. doi: 10.4103/0970-4388.79954.
2
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.SLX4，一种结构特异性内切酶的协调蛋白，在一种新的范可尼贫血亚型中发生突变。
Nat Genet. 2011 Feb;43(2):138-41. doi: 10.1038/ng.751. Epub 2011 Jan 16.
3
Free fibular flap reconstruction of the mandible in a patient with Fanconi anemia.范可尼贫血患者下颌骨的游离腓骨瓣重建术
Plast Reconstr Surg. 2010 Feb;125(2):61e-63e. doi: 10.1097/PRS.0b013e3181c72625.
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Hematopoietic stem cell transplantation in childhood inherited bone marrow failure syndrome.儿童遗传性骨髓衰竭综合征中的造血干细胞移植
Bone Marrow Transplant. 2008 Jan;41(2):127-32. doi: 10.1038/sj.bmt.1705960. Epub 2007 Dec 17.
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Fanconi's anemia: clinical and radiographic oral manifestations.范科尼贫血：临床及影像学口腔表现
Oral Dis. 2007 May;13(3):291-5. doi: 10.1111/j.1601-0825.2006.01282.x.
6
Squamous cell carcinoma of the tongue after bone marrow transplantation in a patient with Fanconi anemia.范可尼贫血患者骨髓移植后发生的舌鳞状细胞癌。
Braz Dent J. 2006;17(2):161-5. doi: 10.1590/s0103-64402006000200015.
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Fanconi anemia manifesting as a squamous cell carcinoma of the hard palate: a case report.表现为硬腭鳞状细胞癌的范可尼贫血：一例报告
Head Face Med. 2006 Jan 13;2:1. doi: 10.1186/1746-160X-2-1.
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Dental procedures in adult patients with hereditary bleeding disorders: 10 years experience in three Italian Hemophilia Centers.成年遗传性出血性疾病患者的牙科治疗：意大利三个血友病中心的10年经验
Haemophilia. 2005 Sep;11(5):504-9. doi: 10.1111/j.1365-2516.2005.01132.x.
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Management options for dental extraction in hemophiliacs: a study of 55 extractions (2000-2002).血友病患者拔牙的管理方案：对55例拔牙病例的研究（2000 - 2002年）
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Mar;99(3):270-5. doi: 10.1016/j.tripleo.2004.06.071.
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Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia.BRCA2基因的种系突变：对乳腺癌、早发性白血病和范可尼贫血的共同遗传易感性。
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