Mohamadkhani Ashraf, Katoonizadeh Aezam, Poustchi Hossein
1. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Middle East J Dig Dis. 2015 Jan;7(1):5-13.
Successful clearance of hepatitis B virus (HBV) is a promising event in which host's immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide association studies (GWAS) has confirmed polymorphisms in the human leukocyte antigen (HLA)-DP locus associated with spontaneous HBV clearance. In this review the impact of host immune response in declining HBsAg during the natural history of the infection has been discussed.
乙型肝炎病毒（HBV）的成功清除是一个充满希望的事件，在此过程中宿主免疫系统会试图清除病毒。HBsAg血清学清除的免疫事件在自然史研究和治疗试验中都备受关注。最近的全基因组关联研究（GWAS）已经证实人类白细胞抗原（HLA）-DP基因座中的多态性与HBV自然清除相关。在这篇综述中，我们讨论了宿主免疫反应在感染自然史中降低HBsAg水平方面的影响。
