慢性乙型肝炎中HBsAg清除的免疫调节事件：聚焦于HLA-DP
Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP.
作者信息
Mohamadkhani Ashraf, Katoonizadeh Aezam, Poustchi Hossein
机构信息
1. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Middle East J Dig Dis. 2015 Jan;7(1):5-13.
Abstract
Successful clearance of hepatitis B virus (HBV) is a promising event in which host's immune system will attempt to get rid of the virus. The immunological events of HBsAg seroclearance have attracted great attention in both natural history investigations and therapeutic trials. Recent genome-wide association studies (GWAS) has confirmed polymorphisms in the human leukocyte antigen (HLA)-DP locus associated with spontaneous HBV clearance. In this review the impact of host immune response in declining HBsAg during the natural history of the infection has been discussed.
摘要
乙型肝炎病毒（HBV）的成功清除是一个充满希望的事件，在此过程中宿主免疫系统会试图清除病毒。HBsAg血清学清除的免疫事件在自然史研究和治疗试验中都备受关注。最近的全基因组关联研究（GWAS）已经证实人类白细胞抗原（HLA）-DP基因座中的多态性与HBV自然清除相关。在这篇综述中，我们讨论了宿主免疫反应在感染自然史中降低HBsAg水平方面的影响。
相似文献
1
Immune-Regulatory Events in the Clearance of HBsAg in Chronic Hepatitis B: Focuses on HLA-DP.慢性乙型肝炎中HBsAg清除的免疫调节事件：聚焦于HLA-DP
Middle East J Dig Dis. 2015 Jan;7(1):5-13.
2
HLA-DP and IL28B polymorphisms: influence of host genome on hepatitis B surface antigen seroclearance in chronic hepatitis B.HLA-DP 和 IL28B 多态性：宿主基因组对慢性乙型肝炎乙型肝炎表面抗原血清学清除的影响。
Clin Infect Dis. 2013 Jun;56(12):1695-703. doi: 10.1093/cid/cit121. Epub 2013 Feb 28.
3
Association between chronic hepatitis B virus infection and HLA-DP gene polymorphisms in the Turkish population.土耳其人群中慢性乙型肝炎病毒感染与HLA-DP基因多态性之间的关联。
Virus Res. 2017 Mar 15;232:6-12. doi: 10.1016/j.virusres.2017.01.017. Epub 2017 Jan 22.
4
Genetic variants in human leukocyte antigen/DP-DQ influence both hepatitis B virus clearance and hepatocellular carcinoma development.人类白细胞抗原/DP-DQ 中的遗传变异既影响乙型肝炎病毒清除，也影响肝细胞癌的发展。
Hepatology. 2012 May;55(5):1426-31. doi: 10.1002/hep.24799. Epub 2012 Mar 16.
5
Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development.HLA-DP常见基因变异与乙型肝炎病毒感染、清除及肝细胞癌发生发展的定量评估。
Sci Rep. 2015 Oct 14;5:14933. doi: 10.1038/srep14933.
6
HLA DPB1 15:01 Allele Predicts Spontaneus Hepatitis B Surface Antigen Seroconversion.HLA DPB1 15:01等位基因可预测自发性乙肝表面抗原血清学转换。
Acta Gastroenterol Belg. 2017 Jul-Sep;80(3):351-355.
7
Association of human leukocyte antigen DP/DQ gene polymorphisms with chronic hepatitis B in Chinese Han and Uygur populations.中国汉族和维吾尔族人群中人类白细胞抗原DP/DQ基因多态性与慢性乙型肝炎的相关性
Infect Genet Evol. 2016 Sep;43:407-11. doi: 10.1016/j.meegid.2016.06.022. Epub 2016 Jun 9.
8
Fine mapping analysis of HLA-DP/DQ gene clusters on chromosome 6 reveals multiple susceptibility loci for HBV infection.对6号染色体上HLA-DP/DQ基因簇的精细定位分析揭示了乙肝病毒感染的多个易感位点。
Amino Acids. 2015 Dec;47(12):2623-34. doi: 10.1007/s00726-015-2054-6. Epub 2015 Jul 22.
9
High hepatitis B virus surface antigen levels and favorable interleukin 28B genotype predict spontaneous hepatitis C virus clearance in uremic patients.高乙肝表面抗原水平和有利的白细胞介素 28B 基因型可预测尿毒症患者自发性丙型肝炎病毒清除。
J Hepatol. 2014 Feb;60(2):253-9. doi: 10.1016/j.jhep.2013.09.023. Epub 2013 Oct 2.
10
Association of HLA-DP/DQ, STAT4 and IL-28B variants with HBV viral clearance in Tibetans and Uygurs in China.中国藏族和维吾尔族中HLA-DP/DQ、STAT4及IL-28B基因变异与乙肝病毒清除的相关性
Liver Int. 2015 Mar;35(3):886-96. doi: 10.1111/liv.12643. Epub 2014 Aug 5.
引用本文的文献
1
Fitting logistic regression models to assess vitamin D deficiency with clinical parameters in chronic hepatitis B patients.拟合逻辑回归模型以通过慢性乙型肝炎患者的临床参数评估维生素D缺乏情况。
Infect Dis Model. 2021 Mar 24;6:612-617. doi: 10.1016/j.idm.2021.03.008. eCollection 2021.
2
Significant SNPs Related to Telomere Length and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Carriers.慢性乙型肝炎携带者中与端粒长度及肝细胞癌风险相关的重要单核苷酸多态性
Asian Pac J Cancer Prev. 2018 Mar 27;19(3):585-590. doi: 10.22034/APJCP.2018.19.3.585.
3
Hepatitis B vaccination coverage, knowledge and sociodemographic determinants of uptake in high risk public safety workers in Kaduna State, Nigeria: a cross sectional survey.尼日利亚卡杜纳州高危公共安全工作者的乙肝疫苗接种覆盖率、知识水平及接种的社会人口学决定因素：一项横断面调查
BMJ Open. 2017 Jun 2;7(5):e015845. doi: 10.1136/bmjopen-2017-015845.
4
Inverse Association of Plasma Level of Glutathione Peroxidase with Liver Fibrosis in Chronic Hepatitis B: Potential Role of Iron.慢性乙型肝炎患者血浆谷胱甘肽过氧化物酶水平与肝纤维化的负相关：铁的潜在作用
Middle East J Dig Dis. 2016 Apr;8(2):122-30. doi: 10.15171/mejdd.2016.17.
5
Clinical Relevance of HLA Gene Variants in HBV Infection.HBV 感染中 HLA 基因变异的临床意义。
J Immunol Res. 2016;2016:9069375. doi: 10.1155/2016/9069375. Epub 2016 May 8.
6
Negative Association of Plasma Levels of Vitamin D and miR-378 With Viral Load in Patients With Chronic Hepatitis B Infection.慢性乙型肝炎感染患者血浆维生素D和miR-378水平与病毒载量的负相关关系。
Hepat Mon. 2015 Jun 23;15(6):e28315. doi: 10.5812/hepatmon.28315v2. eCollection 2015 Jun.
本文引用的文献
1
Hepatocellular carcinoma in the world and the middle East.全球及中东地区的肝细胞癌
Middle East J Dig Dis. 2010 Jan;2(1):31-41.
2
The Possible Role of TLR2 in Chronic Hepatitis B Patients with Precore Mutation.Toll样受体2在乙肝前C区变异慢性乙肝患者中的可能作用
Adv Virol. 2013;2013:780319. doi: 10.1155/2013/780319. Epub 2013 Sep 25.
3
Quantitative prediction of peptide binding to HLA-DP1 protein.肽与HLA - DP1蛋白结合的定量预测
IEEE/ACM Trans Comput Biol Bioinform. 2013 May-Jun;10(3):811-5. doi: 10.1109/TCBB.2013.78.
4
The potential role of APOBEC3G in limiting replication of hepatitis B virus.载脂蛋白B编辑酶催化多肽样蛋白3G在限制乙型肝炎病毒复制中的潜在作用。
Arab J Gastroenterol. 2012 Dec;13(4):170-3. doi: 10.1016/j.ajg.2012.08.001. Epub 2013 Jan 8.
5
Seroprevalence of hepatitis B surface antigen and anti hepatitis C antibody in zahedan city, iran: a population-based study.伊朗扎黑丹市乙肝表面抗原和抗丙型肝炎抗体的血清流行率：一项基于人群的研究。
Hepat Mon. 2012 Sep;12(9):e6618. doi: 10.5812/hepatmon.6618. Epub 2012 Sep 30.
6
Influence of B cells in liver fibrosis associated with hepatitis B virus harboring basal core promoter mutations.乙型肝炎病毒基础核心启动子突变相关肝纤维化中 B 细胞的影响。
J Med Virol. 2012 Dec;84(12):1889-96. doi: 10.1002/jmv.23410.
7
Altered functions of plasmacytoid dendritic cells and reduced cytolytic activity of natural killer cells in patients with chronic HBV infection.慢性乙型肝炎病毒感染者浆细胞样树突状细胞功能改变和自然杀伤细胞细胞毒性活性降低。
Gastroenterology. 2012 Dec;143(6):1586-1596.e8. doi: 10.1053/j.gastro.2012.08.046. Epub 2012 Sep 6.
8
Relationship between HLA-DR gene polymorphisms and outcomes of hepatitis B viral infections: a meta-analysis.HLA-DR 基因多态性与乙型肝炎病毒感染结局的关系：荟萃分析。
World J Gastroenterol. 2012 Jun 28;18(24):3119-28. doi: 10.3748/wjg.v18.i24.3119.
9
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.全基因组关联研究确认 HLA-DP 与日本和韩国慢性乙型肝炎的保护和病毒清除有关。
PLoS One. 2012;7(6):e39175. doi: 10.1371/journal.pone.0039175. Epub 2012 Jun 21.
10
Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.乙型肝炎病毒诱导的脂质改变有助于自然杀伤 T 细胞依赖的保护性免疫。
Nat Med. 2012 Jul;18(7):1060-8. doi: 10.1038/nm.2811.
Zotero 插件