Kamchatnov P R, Evzelman M A, Abusueva B A, Volkov A I
Zh Nevrol Psikhiatr Im S S Korsakova. 2014;114(11):139-44.
Treatment of neuropathic pain (NP) is a serious medical problem. Antiepileptic drugs and antidepressants, used to relief pain, act on the central pain mechanisms and cause several side-effects, thus substantially restricting possibilities of their clinical application.At the same time, NP often has a peripheral component. Ligand-associated channels, including vanilloid receptors TRPV1, play a key role in the development of regional NP syndromes. Capsaicin, a component of chili pepper and several other plants, is a highly selective ligand of TRPV1 receptors and has long been used in treatment of pain syndromes. However, its using is limited by short-term action and relatively low efficacy. Recently it has been shown that the local use of single high doses of capsaicin during 30-60 min causes a marked stable(> 12 weeks) effect. The decrease in NP (>50%) is seen in about half of patients. Current studies will allow to single out groups of patients with the maximal treatment effect of capsaicin.
神经性疼痛（NP）的治疗是一个严重的医学问题。用于缓解疼痛的抗癫痫药物和抗抑郁药物作用于中枢疼痛机制，并会引起多种副作用，从而极大地限制了它们的临床应用可能性。与此同时，NP通常有外周成分。包括香草酸受体TRPV1在内的配体相关通道在局部NP综合征的发生发展中起关键作用。辣椒素是辣椒和其他几种植物的一种成分，是TRPV1受体的高度选择性配体，长期以来一直用于治疗疼痛综合征。然而，其应用受到短期作用和相对较低疗效的限制。最近有研究表明，在30 - 60分钟内局部使用单次高剂量辣椒素会产生显著的稳定（> 12周）效果。约一半的患者NP有所减轻（> 50%）。目前的研究将有助于找出对辣椒素治疗效果最佳的患者群体。
