Price L H, Ricaurte G A, Krystal J H, Heninger G R
Department of Psychiatry, Yale University School of Medicine, New Haven, CN.
Arch Gen Psychiatry. 1989 Jan;46(1):20-2. doi: 10.1001/archpsyc.1989.01810010022003.
3,4-Methylenedioxymethamphetamine (MDMA; "ecstasy") is a selective serotonin (5-HT) neurotoxin in laboratory animals. To assess its effects on 5-HT function in humans, serum prolactin (PRL) and mood responses to intravenous L-tryptophan were measured in nine recreational users of MDMA and compared with findings from nine matched healthy controls. L-Tryptophan induced a rise in the PRL concentration in controls, but not in MDMA users. Peak change and the area under the curve of the PRL response appeared to be blunted in MDMA users, but the difference from controls did not reach statistical significance. This study provides suggestive evidence of altered 5-HT function in MDMA users, but more definitive studies clearly are needed.
3,4-亚甲基二氧甲基苯丙胺（摇头丸；“迷魂药”）在实验动物中是一种选择性血清素（5-羟色胺，5-HT）神经毒素。为评估其对人体5-HT功能的影响，对9名摇头丸娱乐使用者测量了血清催乳素（PRL）以及静脉注射L-色氨酸后的情绪反应，并与9名匹配的健康对照者的结果进行比较。L-色氨酸可使对照者的PRL浓度升高，但在摇头丸使用者中则不然。摇头丸使用者中PRL反应的峰值变化和曲线下面积似乎减弱，但与对照者的差异未达到统计学意义。本研究提供了摇头丸使用者5-HT功能改变的提示性证据，但显然需要更确切的研究。
