慢性胰腺炎患者胰液中前列腺素E2浓度升高，这有助于早期疾病的检测。
Pancreatic juice prostaglandin e2 concentrations are elevated in chronic pancreatitis and improve detection of early disease.
作者信息
Abu Dayyeh Barham K, Conwell Darwin, Buttar Navtej S, Kadilaya Vivek, Hart Philip A, Baumann Nikola A, Bick Benjamin L, Chari Suresh T, Chowdhary Sonia, Clain Jonathan E, Gleeson Ferga C, Lee Linda S, Levy Michael J, Pearson Randall K, Petersen Bret T, Rajan Elizabeth, Steen Hanno, Suleiman Shadeah, Banks Peter A, Vege Santhi S, Topazian Mark
机构信息
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
The Center for Pancreatic Disease, Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, Massachusetts, USA.
出版信息
Clin Transl Gastroenterol. 2015 Jan 29;6(1):e72. doi: 10.1038/ctg.2014.23.
OBJECTIVES
Chronic pancreatitis (CP) may be difficult to diagnose in early stages. We aimed to measure pancreatic juice (PJ) prostaglandin E2 (PGE2) concentrations to determine whether they are elevated in CP and improve diagnosis of early disease.
METHODS
We measured PJ PGE2 in 10 patients with established CP, 25 patients who met criteria for "minimal change" chronic pancreatitis (MCCP), and 10 normal control participants.
RESULTS
Median PJ PGE2 was elevated in CP (307 pg/ml, IQR (249-362)) and MCCP (568 pg/ml, (418-854)) compared with normal controls (104 pg/ml, (68-206)) (P≤ 0.001). Area under receiving operator curve (AUROC) for diagnosis of CP and MCCP was 0.9 and 0.62, respectively, for PJ bicarbonate concentration alone; AUROC was 1.0 and 0.94 for the combination of PJ bicarbonate and PGE2 concentrations.
CONCLUSIONS
PJ PGE2 appears to be a biomarker for CP and is elevated in both established and "minimal change" chronic pancreatitis.
目的
慢性胰腺炎（CP）在早期可能难以诊断。我们旨在测量胰液（PJ）中前列腺素E2（PGE2）的浓度，以确定其在CP中是否升高，并改善早期疾病的诊断。
方法
我们测量了10例确诊为CP的患者、25例符合“微小变化”慢性胰腺炎（MCCP）标准的患者以及10名正常对照者的PJ PGE2。
结果
与正常对照者（104 pg/ml，（68 - 206））相比，CP患者（307 pg/ml，IQR（249 - 362））和MCCP患者（568 pg/ml，（418 - 854））的PJ PGE2中位数升高（P≤0.001）。仅PJ碳酸氢盐浓度用于诊断CP和MCCP的受试者工作特征曲线下面积（AUROC）分别为0.9和0.62；PJ碳酸氢盐和PGE2浓度联合检测的AUROC分别为1.0和0.94。
结论
PJ PGE2似乎是CP的一种生物标志物，在确诊的和“微小变化”的慢性胰腺炎中均升高。
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