线粒体氧消耗的体内评估。
In vivo assessment of mitochondrial oxygen consumption.
作者信息
Harms Floor A, Mik Egbert G
机构信息
Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus MC - University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
出版信息
Methods Mol Biol. 2015;1264:219-29. doi: 10.1007/978-1-4939-2257-4_20.
The protoporphyrin IX-triplet state lifetime technique (PpIX-TSLT) has been proposed by us as a potential clinical noninvasive tool for monitoring mitochondrial function. We have been working on the development of mitochondrial respirometry for monitoring mitochondrial oxygen tension (mitoPO2) and mitochondrial oxygen consumption (mitoVO2) in skin. In this work we describe the principles of the method in experimental animals.
我们提出了原卟啉IX三线态寿命技术（PpIX-TSLT），作为一种潜在的监测线粒体功能的临床无创工具。我们一直在致力于开发用于监测皮肤中线粒体氧张力（mitoPO2）和线粒体氧消耗（mitoVO2）的线粒体呼吸测定法。在这项工作中，我们描述了该方法在实验动物中的原理。
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