Hsiao Wen-Tien, Lin Li-Hsiang, Chiang Hsi-Jen, Ou Keng-Liang, Cheng Han-Yi
Department of Diagnostic Radiology, Taipei Medical University Hospital, Taipei, 110, Taiwan.
J Mater Sci Mater Med. 2015 Feb;26(2):77. doi: 10.1007/s10856-015-5416-4. Epub 2015 Jan 29.
The aim of the present study was to investigate the thermal injury in the liver after a minimally invasive electrosurgery technique with a copper-doped diamond-like carbon (DLC-Cu) surface coating. To effectively utilize electrosurgery in a clinical caner setting, it is necessary to suppress the thermal injury to adjacent tissues. The surface morphologies of DLC-Cu thin films were characterized using scanning electron microscopy and transmission electron microscopy. Three-dimensional liver models were reconstructed using magnetic resonance imaging to simulate the electrosurgical procedure. Our results indicated that the temperature decreased significantly when minimally electrosurgery with nanostructured DLC-Cu thin films was used, and that it continued to decrease with increasing film thickness. In an animal model, thermography revealed that the surgical temperature was significantly lower in the minimally invasive electrosurgery with DLC-Cu thin film (DLC-Cu-SS) compared to untreated electrosurgery. In addition, DLC-Cu-SS created a relatively small thermal injury area and lateral thermal effect. These results indicated that the biomedical nanostructure coating reduced excessive thermal injury, and uniformly distributed temperature in the liver.
本研究的目的是调查采用铜掺杂类金刚石碳（DLC-Cu）表面涂层的微创电外科技术后肝脏中的热损伤情况。为了在临床癌症治疗中有效利用电外科技术，抑制对邻近组织的热损伤是必要的。使用扫描电子显微镜和透射电子显微镜对DLC-Cu薄膜的表面形态进行了表征。利用磁共振成像重建三维肝脏模型以模拟电外科手术过程。我们的结果表明，当使用具有纳米结构的DLC-Cu薄膜进行微创电外科手术时，温度显著降低，并且随着薄膜厚度增加温度持续降低。在动物模型中，热成像显示，与未处理的电外科手术相比，采用DLC-Cu薄膜的微创电外科手术（DLC-Cu-SS）的手术温度显著更低。此外，DLC-Cu-SS造成的热损伤区域和侧向热效应相对较小。这些结果表明，生物医学纳米结构涂层减少了过度的热损伤，并使肝脏中的温度均匀分布。
