Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, USA
Department of Medical Microbiology and Immunology, University of Toledo College of Medicine, Toledo, Ohio, USA.
J Leukoc Biol. 2015 Oct;98(4):489-96. doi: 10.1189/jlb.1MR1014-502R. Epub 2015 Jan 28.
Accumulating lines of evidence now demonstrate that neutrophils can participate in adaptive immune responses directly or indirectly. Even more striking is their potential to acquire phenotypic and functional properties that are typically reserved for professional APCs. These newly emerging concepts of neutrophil heterogeneity and plasticity now challenge the classic view of neutrophils as terminally differentiated leukocytes fully committed to phagocyte functionality. Here, we present a brief overview of our current understanding of neutrophil plasticity by focusing on the acquisition of DC-like properties in culture and at sites of inflammation. Human and murine neutrophils acquire surface expression of MHC II, costimulatory molecules, and other surface markers of DCs when cultured in the presence of selected cytokines. The resulting populations also exhibit potent APC activities to present various antigens to T cells. "Unusual" neutrophils expressing DC markers have been detected in inflammatory lesions in human patients and mouse disease models. These findings imply that acquisition of DC-like properties by neutrophils at the sites of inflammation may represent a key process for linking the innate and adaptive arms of immune responses.
越来越多的证据表明，中性粒细胞可以直接或间接地参与适应性免疫反应。更引人注目的是，它们有可能获得通常专门为专业 APC 保留的表型和功能特性。这些关于中性粒细胞异质性和可塑性的新出现的概念，现在挑战了中性粒细胞作为终末分化的白细胞、完全致力于吞噬功能的经典观点。在这里，我们通过关注在培养中和炎症部位获得 DC 样特性来简要概述我们目前对中性粒细胞可塑性的理解。当在选定的细胞因子存在下培养时，人源和鼠源中性粒细胞获得 MHC II、共刺激分子和 DC 其他表面标志物的表面表达。由此产生的群体也表现出强大的 APC 活性，以向 T 细胞呈递各种抗原。在人类患者的炎症病变和小鼠疾病模型中已经检测到表达 DC 标志物的“异常”中性粒细胞。这些发现表明，在炎症部位中性粒细胞获得 DC 样特性可能代表连接固有和适应性免疫反应的关键过程。
