法国人群中，单倍型B（XV - 2c，等位基因1；KM - 19，等位基因2）与囊性纤维化等位基因之间连锁不平衡的确认。
Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population.
作者信息
Vidaud M, Kitzis A, Ferec C, Bozon D, Dumur V, Giraud G, David F, Pascal O, Auvinet M, Morel Y
机构信息
INSERM U. 91, Hôpital H. Mondor, Créteil, France.
出版信息
Hum Genet. 1989 Jan;81(2):183-4. doi: 10.1007/BF00293899.
In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.
在237个患有囊性纤维化（CF）的法国家庭中，通过两个与CF等位基因紧密连锁的DNA探针XV - 2c和KM - 19检测到了限制性片段长度多态性（RFLP）。与其他欧洲人群一样，单倍型B（XV - 2c，等位基因1；KM - 19，等位基因2）与CF等位基因之间存在连锁不平衡。连锁不平衡改变了携带特定单倍型的人成为携带者的概率。
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