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法国人群中，单倍型B（XV - 2c，等位基因1；KM - 19，等位基因2）与囊性纤维化等位基因之间连锁不平衡的确认。

Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population.

作者信息

Vidaud M, Kitzis A, Ferec C, Bozon D, Dumur V, Giraud G, David F, Pascal O, Auvinet M, Morel Y

机构信息

INSERM U. 91, Hôpital H. Mondor, Créteil, France.

出版信息

Hum Genet. 1989 Jan;81(2):183-4. doi: 10.1007/BF00293899.

DOI:10.1007/BF00293899
PMID:2563252
Abstract

In 237 French families with cystic fibrosis (CF) restricted fragment length polymorphisms (RFLPs) were detected by two DNA probes, XV-2c and KM-19, which are tightly linked to the CF allele. As in other European populations linkage disequilibrium is found between the haplotype B (XV-2c, allele 1: KM-19, allele 2) and the CF allele. Linkage disequilibrium alters the probability that a person bearing a given haplotype is a carrier.

摘要

在237个患有囊性纤维化（CF）的法国家庭中，通过两个与CF等位基因紧密连锁的DNA探针XV - 2c和KM - 19检测到了限制性片段长度多态性（RFLP）。与其他欧洲人群一样，单倍型B（XV - 2c，等位基因1；KM - 19，等位基因2）与CF等位基因之间存在连锁不平衡。连锁不平衡改变了携带特定单倍型的人成为携带者的概率。

相似文献

1
Confirmation of linkage disequilibrium between haplotype B (XV-2c, allele 1; KM-19, allele 2) and cystic fibrosis allele in the French population.法国人群中，单倍型B（XV - 2c，等位基因1；KM - 19，等位基因2）与囊性纤维化等位基因之间连锁不平衡的确认。
Hum Genet. 1989 Jan;81(2):183-4. doi: 10.1007/BF00293899.
2
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引用本文的文献

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Why is the cystic fibrosis gene so frequent?为什么囊性纤维化基因如此常见？
Hum Genet. 1989 Dec;84(1):1-5. doi: 10.1007/BF00210660.
3
Linkage disequilibrium between cystic fibrosis and linked DNA polymorphisms at two DNA markers, XV-2c and KM. 19, in North African families.在北非家庭中，囊性纤维化与两个DNA标记XV - 2c和KM. 19处的连锁DNA多态性之间的连锁不平衡。

本文引用的文献

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