Kaza E, Symonds-Tayler R, Collins D J, McDonald F, McNair H A, Scurr E, Koh D-M, Leach M O
CR-UK Cancer Imaging Centre, Institute of Cancer Research London and Royal Marsden Hospital, London, UK.
Phys Med Biol. 2015 Feb 21;60(4):1681-96. doi: 10.1088/0031-9155/60/4/1681. Epub 2015 Jan 29.
A commercial active breathing coordinator (ABC) device, employed to hold respiration at a specific level for a predefined duration, was successfully adapted for magnetic resonance imaging (MRI) use for the first time. Potential effects of the necessary modifications were assessed and taken into account. Automatic MR acquisition during ABC breath holding was achieved. The feasibility of MR-ABC thoracic and abdominal examinations together with the advantages of imaging in repeated ABC-controlled breath holds were demonstrated on healthy volunteers. Five lung cancer patients were imaged under MR-ABC, visually confirming the very good intra-session reproducibility of organ position in images acquired with the same patient positioning as used for computed tomography (CT). Using identical ABC settings, good MR-CT inter-modality registration was achieved. This demonstrates the value of ABC, since application of T1, T2 and diffusion weighted MR sequences provides a wider range of contrast mechanisms and additional diagnostic information compared to CT, thus improving radiotherapy treatment planning and assessment.
首次成功将一种用于在预定时间段内将呼吸保持在特定水平的商用主动呼吸协调器（ABC）设备适配用于磁共振成像（MRI）。对必要修改的潜在影响进行了评估并加以考虑。实现了在ABC屏气期间的自动MR采集。在健康志愿者身上证明了MR-ABC胸部和腹部检查的可行性以及在重复的ABC控制屏气中成像的优势。对5名肺癌患者进行了MR-ABC成像，直观地证实了在与计算机断层扫描（CT）相同的患者定位下采集的图像中器官位置具有非常好的扫描间期可重复性。使用相同的ABC设置，实现了良好的MR-CT模态间配准。这证明了ABC的价值，因为与CT相比，应用T1、T2和扩散加权MR序列可提供更广泛的对比机制和额外的诊断信息，从而改善放射治疗的治疗计划和评估。
