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作为癌症化疗纳米医学平台的软物质组装体:从市售产品到新方法的历程。

Soft matter assemblies as nanomedicine platforms for cancer chemotherapy: a journey from market products towards novel approaches.

作者信息

Jäger Eliézer, Giacomelli Fernando C

机构信息

Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil.

出版信息

Curr Top Med Chem. 2015;15(4):328-44. doi: 10.2174/1568026615666150130152300.

Abstract

The current review aims to outline the likely medical applications of nanotechnology and the potential of the emerging field of nanomedicine. Nanomedicine can be defined as the investigation area encompassing the design of diagnostics and therapeutics at the nanoscale, including nanobots, nanobiosensors, nanoparticles and other nanodevices, for the remediation, prevention and diagnosis of a variety of illnesses. The ultimate goal of nanomedicine is to improve patient quality-of-life. Because nanomedicine includes the rational design of an enormous number of nanotechnology-based products focused on miscellaneous diseases, a variety of nanomaterials can be employed. Therefore, this review will focus on recent advances in the manufacture of soft matterbased nanomedicines specifically designed to improve diagnostics and cancer chemotherapy efficacy. It will be particularly highlighted liposomes, polymer-drug conjugates, drug-loaded block copolymer micelles and biodegradable polymeric nanoparticles, emphasizing the current investigations and potential novel approaches towards overcoming the remaining challenges in the field as well as formulations that are in clinical trials and marketed products.

摘要

本综述旨在概述纳米技术可能的医学应用以及新兴的纳米医学领域的潜力。纳米医学可定义为一个研究领域,涵盖在纳米尺度上设计诊断和治疗手段,包括纳米机器人、纳米生物传感器、纳米颗粒和其他纳米装置,用于各种疾病的修复、预防和诊断。纳米医学的最终目标是提高患者的生活质量。由于纳米医学包括针对各种疾病合理设计大量基于纳米技术的产品,因此可以采用多种纳米材料。因此,本综述将聚焦于基于软物质的纳米药物制造方面的最新进展,这些纳米药物专门设计用于提高诊断和癌症化疗疗效。将特别强调脂质体、聚合物 - 药物共轭物、载药嵌段共聚物胶束和可生物降解的聚合物纳米颗粒,着重介绍当前的研究以及克服该领域剩余挑战的潜在新方法,以及正在进行临床试验的制剂和上市产品。

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