Ju Huiming, Yang Yuefei, Sheng Anzhi, Jiang Xing
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China.
Mol Med Rep. 2015 Jun;11(6):4019-24. doi: 10.3892/mmr.2015.3275. Epub 2015 Jan 29.
Skeletal muscle accounts for ~40% of total body mass. The principle functions of skeletal muscle include supporting the body structure, controlling motor movements and storing energy. Rhabdomyosarcoma (RMS) is a skeletal muscle‑derived soft tissue tumor widely occurring in the pediatric population. In previous years, microRNAs (miRNAs) have been demonstrated to be important in skeletal muscle development, function and the pathogenesis of various diseases, including RMS. The present review provided an overview of current knowledge on the muscle‑specific and ubiquitously‑expressed miRNAs involved in skeletal muscle differentiation and their dysregulation in RMS. Additionally, the potential use and challenges of miRNAs as therapeutic targets in this soft‑tissue sarcoma were examined and the future prospects for miRNAs in muscle biology and muscle disorders were discussed.
骨骼肌约占人体总质量的40%。骨骼肌的主要功能包括支撑身体结构、控制运动以及储存能量。横纹肌肉瘤（RMS）是一种起源于骨骼肌的软组织肿瘤，广泛发生于儿童群体。近年来，微小RNA（miRNA）已被证明在骨骼肌发育、功能以及包括RMS在内的各种疾病的发病机制中发挥重要作用。本综述概述了目前关于参与骨骼肌分化的肌肉特异性和广泛表达的miRNA的知识，以及它们在RMS中的失调情况。此外，还研究了miRNA作为这种软组织肉瘤治疗靶点的潜在用途和挑战，并讨论了miRNA在肌肉生物学和肌肉疾病方面的未来前景。
