Lin Jun-Bing, Xu Shi-Ming, Xie Ji-Kang, Li Hong-Yu, Xu Peng-Fei
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Chem Commun (Camb). 2015 Feb 28;51(17):3596-9. doi: 10.1039/c4cc09686j.
An organocatalytic Michael-cyclization cascade of aldehydes with 4-oxa-α,β-unsaturated carboxylic acids has been developed, giving functionalized γ-lactols with high yields and enantioselectivities. The products could be easily transformed into complex trisubstituted γ-lactones and γ-lactams.
已开发出一种醛与4-氧杂-α,β-不饱和羧酸的有机催化迈克尔环化串联反应，可高产率和对映选择性地得到官能化的γ-内酯醇。产物可轻松转化为复杂的三取代γ-内酯和γ-内酰胺。
