Abed Edoardo, Piccardi Marco, Rizzo Daniela, Chiaretti Antonio, Ambrosio Lucia, Petroni Sergio, Parrilla Rosa, Dickmann Anna, Riccardi Riccardo, Falsini Benedetto
Department of Ophthalmology, Catholic University of Sacred Heart, Rome, Italy.
Department of Pediatrics, Catholic University of the Sacred Heart, Rome, Italy.
Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2469-74. doi: 10.1167/iovs.14-16235.
To determine whether the Ganzfeld ERG photopic negative response (PhNR), an assay of inner retinal activity, is altered in childhood optic glioma (OPG).
Seventeen pediatric patients with a diagnosis of OPG, established on neuro-ophthalmologic and brain/orbit magnetic resonance imaging (MRI) criteria, were enrolled. The examination protocol included determination of visual acuity (VA), fundus examination, retinal nerve fiber layer (RNFL) measurement with spectral-domain optical coherence tomography (SD-OCT) and photopic ERG. Fifteen normal children served as control group. Ten of the 17 OPG patients were retested 1 to 3 months after the first examination. Photopic ERGs were recorded after 10 minutes of light adaptation in response to a Ganzfeld flash presented on a steady light-adapting background. Amplitude and peak-time of b-wave and PhNR were measured.
Compared with normal values, PhNR amplitude was significantly reduced (P < 0.0001) in the OPG group. Peak-time of PhNR as well as b-wave amplitude and peak-time were similar in both patients and controls. Losses of PhNR were found in patients with involvement of either anterior or retro-chiasmatic optic pathways. Linear regression analysis showed significant positive correlation between RNFL thickness and PhNR amplitude (r2 = 0.34, P = 0.008). Mean percentage test-retest difference for PhNR amplitude and peak-time was 12% and 6%, respectively.
These findings indicate that flash ERG PhNR can detect a loss of inner retinal function in childhood OPGs supporting the use of this technique, as an adjunct to standard psychophysical and electrophysiological tests, to monitor visual function in OPG.
确定作为视网膜内层活性检测指标的全视野视网膜电图明视负反应（PhNR）在儿童视神经胶质瘤（OPG）中是否发生改变。
纳入17例根据神经眼科及脑/眼眶磁共振成像（MRI）标准确诊为OPG的儿科患者。检查方案包括视力（VA）测定、眼底检查、使用光谱域光学相干断层扫描（SD - OCT）测量视网膜神经纤维层（RNFL）以及明视视网膜电图检查。15名正常儿童作为对照组。17例OPG患者中的10例在首次检查后1至3个月进行了复测。在稳定的光适应背景下呈现全视野闪光，经过10分钟的光适应后记录明视视网膜电图。测量b波和PhNR的振幅及峰时。
与正常值相比，OPG组的PhNR振幅显著降低（P < 0.0001）。患者和对照组的PhNR峰时以及b波振幅和峰时相似。在前视路或视交叉后视路受累的患者中均发现PhNR降低。线性回归分析显示RNFL厚度与PhNR振幅之间存在显著正相关（r2 = 0.34，P = 0.008）。PhNR振幅和峰时的平均重测差异百分比分别为12%和6%。
这些发现表明闪光视网膜电图PhNR可检测儿童OPG中视网膜内层功能的丧失，支持将该技术作为标准心理物理学和电生理检查的辅助手段，用于监测OPG患者的视觉功能。
