免疫使 APOL1 在局灶节段性肾小球硬化症中暴露。
Immunity unmasks APOL1 in collapsing glomerulopathy.
机构信息
Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, Washington, USA.
出版信息
Kidney Int. 2015 Feb;87(2):270-2. doi: 10.1038/ki.2014.325.
PMID:25635718
Abstract
Collapsing glomerulopathy predominantly afflicts patients of African ancestry, often first presenting after the immune system is engaged by another disorder. Nichols et al. now show that collateral induction of pathogenic APOL1 allelic variants in podocytes by the ongoing immune response may be the long-sought-after explanation for the development of collapsing glomerulopathy in these patients.
摘要
塌陷性肾小球病主要影响非洲裔患者，通常在免疫系统被另一种疾病激活后首次出现。Nichols 等人现在表明，持续的免疫反应在足细胞中诱导致病性 APOL1 等位基因变异可能是这些患者发生塌陷性肾小球病的长期寻求的解释。
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