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A common problem in the elderly with an uncommon cause: hypoglycaemia secondary to the Doege-Potter syndrome.老年人中一个由罕见病因导致的常见问题:多伊奇-波特综合征继发低血糖症。
BMJ Case Rep. 2015 Jan 30;2015:bcr2014207995. doi: 10.1136/bcr-2014-207995.
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Mitochondria in cancer cells: what is so special about them?癌细胞中的线粒体:它们有何特别之处?
Trends Cell Biol. 2008 Apr;18(4):165-73. doi: 10.1016/j.tcb.2008.01.006. Epub 2008 Mar 4.
2
Non-islet cell tumour-induced hypoglycaemia: a review of the literature including two new cases.非胰岛细胞瘤所致低血糖症:文献综述并附两例新病例
Endocr Relat Cancer. 2007 Dec;14(4):979-93. doi: 10.1677/ERC-07-0161.
3
FIBRO-SARCOMA OF THE MEDIASTINUM.纵隔纤维肉瘤
Ann Surg. 1930 Nov;92(5):955-60.
4
Solitary fibrous tumor of the pleura with associated hypoglycemia: Doege-Potter syndrome: a case report.伴有低血糖的胸膜孤立性纤维瘤:多伊奇-波特综合征:一例报告
J Thorac Oncol. 2006 Jul;1(6):588-90.
5
Solitary fibrous tumor of the pleura.胸膜孤立性纤维瘤
Cancer Control. 2006 Oct;13(4):264-9. doi: 10.1177/107327480601300403.
6
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria.己糖激酶II:与线粒体结合时,它是癌症的双刃剑,既是恶性肿瘤的促进者,又是守门人。
Oncogene. 2006 Aug 7;25(34):4777-86. doi: 10.1038/sj.onc.1209603.
7
Clinical features of insulin-like growth factor-II producing non-islet-cell tumor hypoglycemia.产生胰岛素样生长因子-II的非胰岛细胞瘤低血糖症的临床特征。
Growth Horm IGF Res. 2006 Aug;16(4):211-6. doi: 10.1016/j.ghir.2006.05.003. Epub 2006 Jul 24.
8
Solitary fibrous tumors of the pleura.胸膜孤立性纤维瘤
Ann Thorac Surg. 2002 Jul;74(1):285-93. doi: 10.1016/s0003-4975(01)03374-4.
9
Study of serum big-insulin-like growth factor (IGF)-II and IGF binding proteins in two patients with extrapancreatic tumor hypoglycemia, using a combination of Western blotting methods.采用多种蛋白质印迹法对两名胰腺外肿瘤性低血糖患者的血清大胰岛素样生长因子(IGF)-II及IGF结合蛋白进行研究。
Eur J Endocrinol. 1998 Sep;139(3):317-22. doi: 10.1530/eje.0.1390317.
10
Increased levels of circulating free insulin-like growth factors in patients with non-islet cell tumour hypoglycaemia.非胰岛细胞瘤低血糖症患者循环中游离胰岛素样生长因子水平升高。
Diabetologia. 1998 May;41(5):589-94. doi: 10.1007/s001250050951.

老年人中一个由罕见病因导致的常见问题:多伊奇-波特综合征继发低血糖症。

A common problem in the elderly with an uncommon cause: hypoglycaemia secondary to the Doege-Potter syndrome.

作者信息

Tay Cheong Kiat Julian, Teoh Hui Lin, Su Su

机构信息

National University of Singapore, Singapore.

Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore.

出版信息

BMJ Case Rep. 2015 Jan 30;2015:bcr2014207995. doi: 10.1136/bcr-2014-207995.

DOI:10.1136/bcr-2014-207995
PMID:25636632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4322282/
Abstract

Falls due to hypoglycaemia in the elderly is usually a complication of diabetic treatment. In the absence of diabetes, hypoglycaemia may be due to insulin or insulin-like producing tumours. The Doege-Potter syndrome is a rare paraneoplastic syndrome, characterised by non-islet cell tumour hypoglycaemia (NICTH) secondary to a solitary fibrous tumour that secretes insulin-like growth factor (IGF) 2. Definitive treatment of hypoglycaemia due to NICTH is by tumour resection. Our patient was a 78-year-old woman admitted after a fall with a facial injury and a history of significant weight loss. Her blood sugar was persistently low despite intravenous dextrose infusion. CT of the thorax revealed a large heterogeneous mass measuring 11.6×16.3×15.6 cm in the right hemithorax. A biopsy of the mass was reported as a solitary fibrous tumour. Biochemical investigations revealed low insulin, C-peptide, IGF-1 and a high IGF-2:IGF-1 ratio, consistent with NICTH. The patient underwent tumour resection and the hypoglycaemia normalised completely immediately after surgery.

摘要

老年人因低血糖导致的跌倒通常是糖尿病治疗的并发症。在没有糖尿病的情况下,低血糖可能是由胰岛素或胰岛素样分泌肿瘤引起的。多伊格 - 波特综合征是一种罕见的副肿瘤综合征,其特征是继发于分泌胰岛素样生长因子(IGF)2的孤立性纤维瘤的非胰岛细胞瘤低血糖症(NICTH)。NICTH所致低血糖症的确定性治疗方法是肿瘤切除术。我们的患者是一名78岁女性,因跌倒致面部受伤入院,有明显体重减轻史。尽管静脉输注葡萄糖,但其血糖持续偏低。胸部CT显示右半胸有一个大小为11.6×16.3×15.6 cm的巨大不均匀肿块。肿块活检报告为孤立性纤维瘤。生化检查显示胰岛素、C肽、IGF - 1水平低,IGF - 2:IGF - 1比值高,符合NICTH。患者接受了肿瘤切除术,术后低血糖立即完全恢复正常。