Tay Cheong Kiat Julian, Teoh Hui Lin, Su Su
National University of Singapore, Singapore.
Department of Geriatric Medicine, Khoo Teck Puat Hospital, Singapore.
BMJ Case Rep. 2015 Jan 30;2015:bcr2014207995. doi: 10.1136/bcr-2014-207995.
Falls due to hypoglycaemia in the elderly is usually a complication of diabetic treatment. In the absence of diabetes, hypoglycaemia may be due to insulin or insulin-like producing tumours. The Doege-Potter syndrome is a rare paraneoplastic syndrome, characterised by non-islet cell tumour hypoglycaemia (NICTH) secondary to a solitary fibrous tumour that secretes insulin-like growth factor (IGF) 2. Definitive treatment of hypoglycaemia due to NICTH is by tumour resection. Our patient was a 78-year-old woman admitted after a fall with a facial injury and a history of significant weight loss. Her blood sugar was persistently low despite intravenous dextrose infusion. CT of the thorax revealed a large heterogeneous mass measuring 11.6×16.3×15.6 cm in the right hemithorax. A biopsy of the mass was reported as a solitary fibrous tumour. Biochemical investigations revealed low insulin, C-peptide, IGF-1 and a high IGF-2:IGF-1 ratio, consistent with NICTH. The patient underwent tumour resection and the hypoglycaemia normalised completely immediately after surgery.
老年人因低血糖导致的跌倒通常是糖尿病治疗的并发症。在没有糖尿病的情况下,低血糖可能是由胰岛素或胰岛素样分泌肿瘤引起的。多伊格 - 波特综合征是一种罕见的副肿瘤综合征,其特征是继发于分泌胰岛素样生长因子(IGF)2的孤立性纤维瘤的非胰岛细胞瘤低血糖症(NICTH)。NICTH所致低血糖症的确定性治疗方法是肿瘤切除术。我们的患者是一名78岁女性,因跌倒致面部受伤入院,有明显体重减轻史。尽管静脉输注葡萄糖,但其血糖持续偏低。胸部CT显示右半胸有一个大小为11.6×16.3×15.6 cm的巨大不均匀肿块。肿块活检报告为孤立性纤维瘤。生化检查显示胰岛素、C肽、IGF - 1水平低,IGF - 2:IGF - 1比值高,符合NICTH。患者接受了肿瘤切除术,术后低血糖立即完全恢复正常。