Abele Jonathan T, Moore Ronald, Tymchak Wayne, Owen Richard J
Department of Radiology and Diagnostic Imaging, Surgery, University of Alberta, 2A2.41 WMC, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7.
Division of Urology, University of Alberta, 2A2.41 WMC, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7.
J Vasc Interv Radiol. 2015 Mar;26(3):418-25. doi: 10.1016/j.jvir.2014.11.018. Epub 2015 Jan 28.
To determine if perfusion of the prostate can be mapped using technetium-99m ((99m)Tc) macroaggregated albumin (MAA) after selective prostate artery catheterization.
Selective prostate artery injections of MAA were performed and analyzed in 14 patients; 9 patients received unilateral injection, and 5 patients received bilateral injections (37 MBq/1 mCi per injection). Fused single-photon emission computed tomography/computed tomography (SPECT/CT) images were subsequently acquired using a fiducial marker technique. Perfusion distribution was assessed, and relative intraprostatic versus extraprostatic activity was quantified and compared between groups.
The percentage of the prostate gland containing activity was significantly greater for the bilateral injection group compared with the unilateral injection group (76.6% vs 44.3%, P < .05). The percentage of relative intraprostatic versus extraprostatic activity was significantly lower for the bilateral injection group compared with the unilateral injection group (40.3% vs 75.9%, P < .05). Sites of visualized extraprostatic activity included the seminal vesicles (8 of 14 patients), internal iliac vessels (7 of 14 patients), bladder wall (5 of 14 patients), space of Retzius (3 of 14 patients), rectal wall (3 of 14 patients), and penis (1 of 14 patients).
Perfusion mapping with (99m)Tc-MAA can be effectively performed with SPECT/CT after selective prostate artery catheterization. The relative percentage of intraprostatic versus extraprostatic activity can be quantified, and the distribution of activity within and outside the prostate gland can be determined.
确定在选择性前列腺动脉插管后，能否使用锝-99m（99mTc）大颗粒白蛋白（MAA）对前列腺灌注进行成像。
对14例患者进行了MAA的选择性前列腺动脉注射并分析；9例患者接受单侧注射，5例患者接受双侧注射（每次注射37MBq/1mCi）。随后使用基准标记技术获取融合的单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）图像。评估灌注分布，并对前列腺内与前列腺外的相对活性进行定量，并在组间进行比较。
双侧注射组前列腺含活性的百分比显著高于单侧注射组（76.6%对44.3%，P<.05）。双侧注射组前列腺内与前列腺外相对活性的百分比显著低于单侧注射组（40.3%对75.9%，P<.05）。可见前列腺外活性的部位包括精囊（14例患者中的8例）、髂内血管（14例患者中的7例）、膀胱壁（14例患者中的5例）、Retzius间隙（14例患者中的3例）、直肠壁（14例患者中的3例）和阴茎（14例患者中的1例）。
在选择性前列腺动脉插管后，使用SPECT/CT可以有效地进行99mTc-MAA灌注成像。可以定量前列腺内与前列腺外活性的相对百分比，并确定前列腺内外的活性分布。
