记忆印迹细胞的识别与操控
Identification and Manipulation of Memory Engram Cells.
作者信息
Liu Xu, Ramirez Steve, Redondo Roger L, Tonegawa Susumu
机构信息
RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
出版信息
Cold Spring Harb Symp Quant Biol. 2014;79:59-65. doi: 10.1101/sqb.2014.79.024901. Epub 2015 Jan 30.
How memories are formed and stored in the brain remains a fascinating question in neuroscience. Here we discuss the memory engram theory, our recent attempt to identify and manipulate memory engram cells in the brain with optogenetics, and how these methods are used to address questions such as how false memory is formed and how the valence of a memory can be changed in the brain.
记忆如何在大脑中形成和存储仍然是神经科学中一个引人入胜的问题。在这里，我们将讨论记忆印迹理论、我们最近尝试用光遗传学识别和操纵大脑中的记忆印迹细胞，以及这些方法如何用于解决诸如错误记忆如何形成以及记忆的效价如何在大脑中改变等问题。
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