Bowery Norman G
Department of Pharmacology, University of Birmingham Medical School, Edgbaston, United Kingdom.
Adv Pharmacol. 2015;73:1-11. doi: 10.1016/bs.apha.2014.11.001. Epub 2015 Jan 14.
I first met Hanns in 1977 and soon learnt of his extraordinary ability as a researcher. He became a friend as well as a mentor providing enthusiasm for my own research. I watched closely over the years how his research uncovered details of the association of the benzodiazepines and GABA and delineated the structural composition of the GABAA receptor associated with the action of individual drugs such as antianxiety and antiepileptic agents. His work produced many important contributions to medicine notable of which was the discovery of the first benzodiazepine antagonists, which are now routinely used in clinical practice. But for me his most important contribution was the discovery of the benzodiazepine receptor. During this time, my group uncovered a novel receptor for GABA and my progress in this work was encouraged and enhanced by discussions with Hanns.
我于1977年首次结识汉斯，很快便了解到他作为一名研究人员的非凡能力。他既是我的朋友，也是我的导师，为我自己的研究注入了热情。多年来，我密切关注着他的研究如何揭示苯二氮卓类药物与γ-氨基丁酸（GABA）之间关联的细节，并描绘出与抗焦虑和抗癫痫药物等个别药物作用相关的GABAA受体的结构组成。他的工作为医学做出了许多重要贡献，其中值得注意的是发现了首批苯二氮卓类拮抗剂，这些拮抗剂如今已在临床实践中常规使用。但对我来说，他最重要的贡献是发现了苯二氮卓受体。在此期间，我的团队发现了一种新型的GABA受体，与汉斯的讨论鼓励并推动了我在这项工作上的进展。
