青少年型系统性红斑狼疮的骨密度
Bone mineral density in juvenile onset systemic lupus erythematosus.
作者信息
Abdwani R, Abdulla E, Yaroubi S, Bererhi H, Al-Zakwani I
机构信息
Departments of Child Health, *Radiology and #Pharmacology and Clinical Pharmacy, Sultan Qaboos University Hospital, Muscat, Oman. Correspondence to: Dr Reem Abdwani, Senior Consultant Pediatric Rheumatologist, Sultan Qaboos University Hospital, Muscat, Oman.
出版信息
Indian Pediatr. 2015 Jan;52(1):38-40. doi: 10.1007/s13312-015-0564-7.
OBJECTIVE
To compare bone mineral density in patients with juvenile-onset Systemic lupus erythematosus and healthy controls.
PARTICIPANTS
Serial bone mineral density measurements in 27 patients with juvenile-onset systemic lupus were compared to 97 healthy age-matched controls.
RESULTS
All patients with juvenile-onset had low bone mineral density scores at initial assessment that progressed over disease course. Low body mass index was independently associated with a decline in bone mineral density Z scores; disease activity, use of immunosuppressive agents and vitamin D levels were not risk factors.
CONCLUSIONS
Patients with juvenile-onset systemic lupus erythematosus have low bone mineral density.
目的
比较青少年起病的系统性红斑狼疮患者与健康对照者的骨密度。
参与者
对27例青少年起病的系统性狼疮患者的系列骨密度测量结果与97例年龄匹配的健康对照者进行比较。
结果
所有青少年起病的患者在初始评估时骨密度评分均较低，且在病程中呈进展趋势。低体重指数与骨密度Z评分下降独立相关；疾病活动度、免疫抑制剂的使用和维生素D水平均不是危险因素。
结论
青少年起病的系统性红斑狼疮患者骨密度较低。
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