Pietrzyk Edward, Gorczyca-Michta Iwona, Michta Kamil, Nowakowska Magdalena, Wożakowska-Kapłon Beata
Psychiatr Pol. 2014 Sep-Oct;48(5):987-96. doi: 10.12740/pp/24426.
Surgical revascularization is a recognized method of treatment ofischaemic heart disease. The number of patients undergoing coronary artery bypass grafting (CABG) is constantly increasing, both in a population of young patients with coronary heart disease and in elderly patients. It is estimated that even one out of three patients undergoing CABG in the perioperative period can develop symptoms of depression. Numerous individual factors as well as factors related to the surgery have an impact on the occurrence of depression. The most common factors are: age, sex, socio-economic status, co-existing diseases, and the occurrence ofpreoperative depression. Researchers are currently looking for biochemical markers concentration of which before surgery could serve as a predicator for the occurrence of post-CABG depression. It is suggested that inflammatory response, particularly intense in the perioperative period, is linked to the occurrence of depression after surgical revascularization. Recognizing these factors is of utmost importance since it will help develop a stratification aiming at the identification of patients who are particularly prone to the occurrence of postoperative depression. Due to the fact that depression not only lowers the quality of life but also affects the short-term and long-term prognosis, identifying patients at risk is significantly important.
外科血管重建术是治疗缺血性心脏病的一种公认方法。接受冠状动脉旁路移植术（CABG）的患者数量在患有冠心病的年轻患者群体和老年患者群体中都在不断增加。据估计，在围手术期接受CABG的患者中，甚至每三人中就有一人会出现抑郁症状。众多个体因素以及与手术相关的因素都会对抑郁的发生产生影响。最常见的因素包括：年龄、性别、社会经济地位、并存疾病以及术前抑郁的发生情况。研究人员目前正在寻找术前其浓度可作为CABG术后抑郁发生预测指标的生化标志物。有人认为，在围手术期尤其强烈的炎症反应与外科血管重建术后抑郁的发生有关。认识到这些因素至关重要，因为这将有助于制定分层策略，旨在识别特别容易发生术后抑郁的患者。由于抑郁不仅会降低生活质量，还会影响短期和长期预后，识别有风险的患者非常重要。
