神经递质在正常和受损大鼠中对杀螟硫磷诱导的攻击行为中的作用。

Role of neurotransmitters in fenitrothion-induced aggressive behaviour in normal and lesioned rats.

作者信息

Anand M, Gulati A, Gopal K, Gupta G S, Chandra S V

机构信息

Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.

出版信息

Toxicol Lett. 1989 Feb;45(2-3):215-20. doi: 10.1016/0378-4274(89)90012-x.

DOI:10.1016/0378-4274(89)90012-x

PMID:2563918

Abstract

Normal and brain-lesioned (amygdala, septal and nigral regions) rats exposed to fenitrothion (10 mg/kg) for 15 subsequent days showed elevated foot-shock fighting behaviour (septal and nigral lesioned rats). Treated animals failed to perform the rotorod test and showed decreased locomotor activity followed by convulsions. The brain-lesioned rats treated with 10 mg/kg fenitrothion showed a marked decrease in the level of norepinephrine (NE) and serotonin (5-HT).

摘要

正常大鼠以及脑部受损（杏仁核、隔区和黑质区域）的大鼠连续15天暴露于杀螟硫磷（10毫克/千克）中，之后表现出足部电击战斗行为增加（隔区和黑质受损大鼠）。接受治疗的动物未能完成转棒试验，运动活动减少，随后出现惊厥。用10毫克/千克杀螟硫磷治疗的脑部受损大鼠去甲肾上腺素（NE）和血清素（5-HT）水平显著降低。