Chan A W, Leong F W, Schanley D L, Welte J W, Wieczorek W, Rej R, Whitney R B
Research Institute on Alcoholism, New York State Division of Alcoholism and Alcohol Abuse, Buffalo.
Drug Alcohol Depend. 1989 Jan;23(1):13-8. doi: 10.1016/0376-8716(89)90028-8.
Two recently proposed biochemical markers of alcoholism, namely, quantitation of plasma transferrin variant (Tf5.7) and the ratio of plasma mitochondrial aspartate aminotransferase (m-AspAT) to total AspAT (t-AspAT), were tested for their ability to detect young adult alcoholics. Another commonly used biochemical test, namely, activity of plasma gamma glutamyltransferase (GGT) was included as a comparison. Although mean values of GGT, TF5.7, total transferrin (Tftot), m-AspAT and t-AspAT in alcoholics were significantly higher than those in controls, there were too many overlapping values in each test between alcoholics and controls to render any of these tests suitable as a marker for young adult alcoholics. Depending on cut-off limits, the sensitivity of each test ranged from 0-52% and the specificity ranged from 80-97%. Moreover, the m-AspAT/t-AspAT and Tf5.7/Tftot ratios were not significantly different between alcoholics and controls. A stepwise linear discriminant function analysis of all the variables resulted in a slight increase in classification sensitivity (66%) but a decrease in specificity (77%). The relatively short duration (mean = 5.6 years) of heavy alcohol intake and the time elapsed (mean = 5.8 days) since the alcoholics last consumed alcohol very likely contributed to the low sensitivity. Young adults might also be more resilient with regard to the damaging biochemical effects of ethanol. Abnormal biochemical values might reverse to normal values much more quickly in young adult alcoholics than in those who are older and have more years of alcohol abuse.
最近提出的两种酒精中毒生化标志物，即血浆转铁蛋白变体（Tf5.7）定量以及血浆线粒体天冬氨酸氨基转移酶（m-AspAT）与总天冬氨酸氨基转移酶（t-AspAT）的比值，被测试用于检测年轻成年酗酒者的能力。另一种常用的生化检测，即血浆γ-谷氨酰转移酶（GGT）活性，被纳入作为比较。尽管酗酒者的GGT、TF5.7、总转铁蛋白（Tftot）、m-AspAT和t-AspAT的平均值显著高于对照组，但酗酒者和对照组在每项检测中的重叠值过多，使得这些检测均不适用于作为年轻成年酗酒者的标志物。根据临界值，每项检测的灵敏度范围为0-52%，特异性范围为80-97%。此外，酗酒者和对照组之间的m-AspAT/t-AspAT和Tf5.7/Tftot比值没有显著差异。对所有变量进行逐步线性判别函数分析，分类灵敏度略有提高（66%），但特异性降低（77%）。大量饮酒的持续时间相对较短（平均=5.6年），且酗酒者最后一次饮酒后经过的时间（平均=5.8天）很可能导致了低灵敏度。年轻成年人可能对乙醇的有害生化影响更具恢复力。年轻成年酗酒者的异常生化值可能比年龄较大且有更多年酗酒史的酗酒者更快恢复到正常值。
