麻疹风疹联合疫苗在具有自然获得性麻疹免疫力的入学年龄儿童中的反应原性和免疫原性。
Reactogenicity and immunogenicity of measles-rubella combined vaccine in school-entry-aged subjects with naturally acquired measles immunity.
作者信息
Kumagai Takuji, Ihara Toshiaki, Nakayama Tetsuo, Nagata Nobuo, Kamiya Hitoshi
机构信息
Pediatric Allergy and Infectious Diseases Society of Sapporo, Kumagai Pediatric Clinic, Sapporo, Japan.
Department of Pediatrics, National Hospital Organization Mie National Hospital, Tsu, Japan.
出版信息
Pediatr Int. 2015 Aug;57(4):597-602. doi: 10.1111/ped.12596. Epub 2015 Apr 28.
BACKGROUND
The reintroduction of measles-rubella combined (MR) vaccination to Japan raised concerns about adverse events as well as immunogenicity related to booster immunization in subjects with naturally acquired immunity to measles or rubella.
METHODS
The time course of reactogenicity and antibody responses in recipients with pre-existing immunity to measles through natural infection was observed. Eighteen children aged 80-104 months received MR booster vaccination; 16 of them had had previous rubella vaccination.
RESULTS
There were virtually no clinical reactions related to booster vaccination, and a highly significant antibody response to rubella antigen, whereas the antibody rise to measles was statistically significant but poor.
CONCLUSIONS
Vaccination of individuals already immune is not harmful. Booster immunization to rubella for Japanese children is vitally important.
背景
日本重新引入麻疹 - 风疹联合（MR）疫苗接种引发了人们对不良事件以及与麻疹或风疹自然获得性免疫个体加强免疫相关的免疫原性的担忧。
方法
观察了通过自然感染对麻疹具有预先存在免疫力的接种者的反应原性和抗体反应的时间进程。18名年龄在80 - 104个月的儿童接受了MR加强疫苗接种；其中16名曾接种过风疹疫苗。
结果
与加强疫苗接种相关的临床反应几乎不存在，对风疹抗原产生了高度显著的抗体反应，而对麻疹的抗体升高虽具有统计学意义但较弱。
结论
对已经免疫的个体进行疫苗接种无害。对日本儿童进行风疹加强免疫至关重要。
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