Han Yu Hao, Abdul Hamid Mas R W, Telisinghe Pemasiri Upali, Haji Hussin Juniadah Binti, Mabruk Mohamed
PAPRSP Institute of Health Sciences, University of Brunei Darussalam, Gadong, Brunei Darussalam E-mail : mohamed.mabruk@.ubd.edu.bn ;
Asian Pac J Cancer Prev. 2015;16(1):233-7. doi: 10.7314/apjcp.2015.16.1.233.
Lung cancer is the leading cause of cancer death in Brunei Darussalam, accounting for almost 20% of the total. The epidermal growth factor receptor (EGFR) is a member of the erbB family of tyrosine kinase receptor proteins, which includes c-erbb2(HER2/neu), erb-B3, and erb-B4. EGFR overexpression is found in a third of all epithelial cancers, often associated with a poor prognosis.
Protein expression of EGFR in 27 cases of lung cancer tissue samples and 9 cases of normal lung tissue samples was evaluated using an immunohistochemical approach.
The results demonstrated significant increase and overexpression of EGFR in Bruneian lung cancer tissue samples in comparison to normal lung tissue. However, there was no significant relationship between clinicopathologic variables (age and sex) of patients and EGFR protein expression.
EGFR is overexpressed in Bruneian lung cancer patient tissue samples in comparison to normal lung tissue samples. This may indicate that EGFR protein over expression plays an important role in the genesis of this type of cancer in Brunei Darussalam.
肺癌是文莱达鲁萨兰国癌症死亡的主要原因，占总数的近20%。表皮生长因子受体（EGFR）是酪氨酸激酶受体蛋白erbB家族的成员，该家族包括c-erbb2（HER2/neu）、erb-B3和erb-B4。在三分之一的上皮癌中发现EGFR过表达，通常与预后不良相关。
采用免疫组织化学方法评估27例肺癌组织样本和9例正常肺组织样本中EGFR的蛋白表达。
结果显示，与正常肺组织相比，文莱肺癌组织样本中EGFR显著增加且过表达。然而，患者的临床病理变量（年龄和性别）与EGFR蛋白表达之间无显著关系。
与正常肺组织样本相比，文莱肺癌患者组织样本中EGFR过表达。这可能表明EGFR蛋白过表达在文莱达鲁萨兰国这类癌症的发生中起重要作用。
