汉族人群中VEGFA基因多态性与精神分裂症的关联研究

Association study of VEGFA polymorphisms with schizophrenia in Han Chinese population.

作者信息

Gao Kerun, Wang Qingzhong, Zhang Yanxia, Wang Dongxiang, Fu Yingmei, Li Huafang, Yu Shunying

机构信息

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wanping Nan Road, Shanghai 200030, China.

出版信息

Neurosci Lett. 2015 Mar 17;590:121-5. doi: 10.1016/j.neulet.2015.01.069. Epub 2015 Jan 29.

DOI:10.1016/j.neulet.2015.01.069

PMID:25641131

Abstract

Vascular endothelial growth factor A (VEGFA) has been implicated in neurotrophy and neurogenesis, which play a pivotal role in brain development and may be involved in the pathophysiology of schizophrenia (SCZ). We hypothesized that common genetic variants in the VEGFA gene may be associated with SCZ. In our study, seven tag single nucleotide polymorphisms (SNPs) within VEGFA were genotyped in 1034 SCZ patients and 952 healthy controls in the Han Chinese population. No significant differences of allele and genotype distributions of the 7 tag SNPs were identified between SCZ patients and healthy controls. The AA genotype of rs699947 nominally decreased the risk of SCZ in recessive inheritance model (p=0.03, OR=0.65, 95%CI=0.44-0.95, adjusted p=0.18). No significant associations were found between different haplotypes and the risk of SCZ (p>0.05). Our findings suggested that the selected tag SNPs of VEGFA may not confer a susceptibility of SCZ in the Han Chinese population.

摘要

血管内皮生长因子A（VEGFA）与神经营养和神经发生有关，这在大脑发育中起关键作用，且可能参与精神分裂症（SCZ）的病理生理学过程。我们假设VEGFA基因中的常见遗传变异可能与SCZ相关。在我们的研究中，对1034例SCZ患者和952例汉族健康对照者进行了VEGFA基因内7个标签单核苷酸多态性（SNP）的基因分型。在SCZ患者和健康对照者之间，未发现这7个标签SNP的等位基因和基因型分布有显著差异。rs699947的AA基因型在隐性遗传模型中名义上降低了SCZ的风险（p = 0.03，OR = 0.65，95%CI = 0.44 - 0.95，校正p = 0.18）。未发现不同单倍型与SCZ风险之间存在显著关联（p>0.05）。我们的研究结果表明，VEGFA选定的标签SNP可能不会使汉族人群易患SCZ。