Liu Lijun, Li Jingjie, Yan Mengdan, Li Jing, Chen Junyu, Zhang Yi, Zhu Xikai, Wang Li, Kang Longli, Yuan Dongya, Jin Tianbo
Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi 712082, China.
Oncotarget. 2017 Apr 25;8(17):28614-28620. doi: 10.18632/oncotarget.15603.
Single nucleotide polymorphisms (SNPs) in TCF7L2 (Transcription Factor 7-Like 2) reportedly affect susceptibility to schizophrenia (SCZ). We examined the association between TCF7L2 polymorphisms and SCZ susceptibility in a Chinese Han population. Six SNPs were genotyped in 499 SCZ patients and 500 healthy individuals, after which their associations with SCZ were evaluated using the Chi-squared test and genetic model analyses. We observed that the allele A of rs12573128 is associated with an increased SCZ risk (odds ratio [OR] = 1.33, 95% confidence interval [CI]: 1.08-1.63, P = 0.006, adjusted P = 0.030). The AA genotype of rs12573128 was associated with a higher SCZ risk than the GG genotype, before and after adjustment for sex and age (adjusted OR = 2.97, 95% CI: 1.49-5.92, P = 0.002). In addition, SNP rs12573128 was associated with 1.47-fold, 2.64-fold and 1.50-fold increases in SCZ risk of in dominant, recessive and additive model, respectively (adjusted OR = 1.47, 95% CI = 1.09-1.99, P = 0.012; Bonferroni adjusted P = 0.030). adjusted OR = 2.64, 95% CI = 1.34-5.18, P = 0.005 and adjusted OR = 1.50, 95% CI = 1.17-1.93, P = 0.002, respectively). These results suggest rs12573128 is significantly associated with an increased risk of SCZ in the Chinese Han population.
据报道，转录因子7样蛋白2（TCF7L2）中的单核苷酸多态性（SNP）会影响精神分裂症（SCZ）的易感性。我们在中国汉族人群中研究了TCF7L2基因多态性与SCZ易感性之间的关联。对499例SCZ患者和500名健康个体的6个SNP进行了基因分型，然后使用卡方检验和遗传模型分析评估它们与SCZ的关联。我们观察到，rs12573128的A等位基因与SCZ风险增加相关（优势比[OR]=1.33，95%置信区间[CI]：1.08-1.63，P=0.006，校正P=0.030）。在对性别和年龄进行校正之前和之后，rs12573128的AA基因型与SCZ风险高于GG基因型相关（校正OR=2.97，95%CI：1.49-5.92，P=0.002）。此外，SNP rs12573128在显性、隐性和加性模型中分别与SCZ风险增加1.47倍、2.64倍和1.50倍相关（校正OR=1.47，95%CI=1.09-1.99，P=0.012；经Bonferroni校正P=0.030）。校正OR分别为2.64，95%CI=1.34-5.18，P=0.005和校正OR=1.50，95%CI=1.17-1.93，P=0.002）。这些结果表明，rs12573128与中国汉族人群中SCZ风险增加显著相关。
