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社会经济地位对肾移植后同种异体肾及患者存活的影响。

Influence of socioeconomic status on allograft and patient survival following kidney transplantation.

作者信息

Ward Frank L, O'Kelly Patrick, Donohue Fionnuala, ÓhAiseadha Coilin, Haase Trutz, Pratschke Jonathan, deFreitas Declan G, Johnson Howard, Conlon Peter J, O'Seaghdha Conall M

机构信息

Department of Transplantation and Renal Medicine, Beaumont Hospital, Dublin, Ireland.

出版信息

Nephrology (Carlton). 2015 Jun;20(6):426-33. doi: 10.1111/nep.12410.

Abstract

AIM

Whether socioeconomic status confers worse outcomes after kidney transplantation is unknown. Its influence on allograft and patient survival following kidney transplantation in Ireland was examined.

METHODS

A retrospective, observational cohort study of adult deceased-donor first kidney transplant recipients from 1990 to 2009 was performed. Those with a valid Irish postal address were assigned a socioeconomic status score based on the Pobal Hasse-Pratschke deprivation index and compared in quartiles. Cox proportional hazards models and Kaplan-Meier survival analysis were used to investigate any significant association of socioeconomic status with patient and allograft outcomes.

RESULTS

A total of 1944 eligible kidney transplant recipients were identified. The median follow-up time was 8.2 years (interquartile range 4.4-13.3 years). Socioeconomic status was not associated with uncensored or death-censored allograft survival (hazard ratio (HR) 1.0, 95% confidence interval (CI) 0.99-1.00, P = 0.33 and HR 1.0, 95% CI 0.99-1.00, P = 0.37, respectively). Patient survival was not associated with socioeconomic status quartile (HR 1.0, 95% CI 0.93-1.08, P = 0.88). There was no significant difference among quartiles for uncensored or death-censored allograft survival at 5 and 10 years.

CONCLUSION

There was no socioeconomic disparity in allograft or patient outcomes following kidney transplantation, which may be partly attributable to the Irish healthcare model. This may give further impetus to calls in other jurisdictions for universal healthcare and medication coverage for kidney transplant recipients.

摘要

目的

肾移植后社会经济地位是否会导致更差的结果尚不清楚。本研究调查了其对爱尔兰肾移植后同种异体移植物和患者生存的影响。

方法

对1990年至2009年成年已故供体首次肾移植受者进行回顾性观察队列研究。根据Pobal Hasse-Pratschke贫困指数为有有效爱尔兰邮政地址的患者分配社会经济地位评分,并按四分位数进行比较。采用Cox比例风险模型和Kaplan-Meier生存分析来研究社会经济地位与患者和同种异体移植物结果之间的任何显著关联。

结果

共确定了1944名符合条件的肾移植受者。中位随访时间为8.2年(四分位间距4.4 - 13.3年)。社会经济地位与未删失或死亡删失的同种异体移植物存活无关(风险比[HR]为1.0,95%置信区间[CI]为0.99 - 1.00,P = 0.33;HR为1.0,95% CI为0.99 - 1.00,P = 0.37)。患者生存与社会经济地位四分位数无关(HR为1.0,95% CI为0.93 - 1.08,P = 0.88)。在5年和10年时,未删失或死亡删失的同种异体移植物存活在四分位数之间没有显著差异。

结论

肾移植后同种异体移植物或患者结果不存在社会经济差异,这可能部分归因于爱尔兰的医疗模式。这可能会进一步推动其他司法管辖区呼吁为肾移植受者提供全民医疗保健和药物覆盖。

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