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2型糖尿病患者的骨密度评估

Bone mineral density evaluation of patients with type 2 diabetes mellitus.

作者信息

Adil Camli, Aydın Teoman, Taşpınar Özgür, Kızıltan Huriye, Eriş Ali Hikmet, Hocaoglu Ilknur Turk, Poşul Sevde, Kepekci Muge, Denizli Ebru, Güler Mustafa

机构信息

Department of Internal Medicine, Faculty of Medicine, Bezmi Alem Vakıf University, Turkey.

Department of Physical Medicine and Rehabilitation: Istanbul, Turkey.

出版信息

J Phys Ther Sci. 2015 Jan;27(1):179-82. doi: 10.1589/jpts.27.179. Epub 2015 Jan 9.

Abstract

[Purpose] Diabetes mellitus is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. A consequence of this is chronic hyperglycemia with disturbances in carbohydrate, fat and protein metabolism. We investigated whether there is any difference among DM patients and a control group in terms of lumbar and femur BMD (bone mineral density), and standard deviation scores (Z score and T score). [Subjects and Methods] This randomized, prospective, controlled, single-blind study was conducted in the Physical Medicine and Rehabilitation Department Faculty of Medicine, Bezm-i Alem Vakıf University. Patients with type 2 diabetes mellitus were included in the patient groups. Healthy individuals were included in the control group. [Results] A total of 126 patients completed the study (63 in the study group, 63 in the control group). There was no significant difference in the results of the laboratory examinations of the cases. The bone mineral densities of the cases were found to be significantly low in terms of the lumbar (L1-4) T scores in the type 2 diabetes group. [Conclusion] Although osteoporosis is one of the potential complications of type 1 diabetes, its effect on bone mineral density in type 2 DM is controversial. In different studies, the bone mineral density values have increased, decreased or remained normal. With the exception of the lumbar (L1-4) T score, similar results were obtained in this study.

摘要

[目的] 糖尿病是一种由胰岛素分泌缺陷、胰岛素作用缺陷或两者兼而有之引起的代谢紊乱。其结果是慢性高血糖,并伴有碳水化合物、脂肪和蛋白质代谢紊乱。我们研究了糖尿病患者与对照组在腰椎和股骨骨密度(BMD)以及标准差分数(Z分数和T分数)方面是否存在差异。[对象与方法] 本随机、前瞻性、对照、单盲研究在贝兹姆-阿勒姆瓦基夫大学医学院物理医学与康复科进行。2型糖尿病患者纳入患者组,健康个体纳入对照组。[结果] 共有126例患者完成研究(研究组63例,对照组63例)。病例的实验室检查结果无显著差异。在2型糖尿病组中,病例的腰椎(L1-4)T分数显示骨密度显著降低。[结论] 虽然骨质疏松症是1型糖尿病的潜在并发症之一,但其对2型糖尿病患者骨密度的影响存在争议。在不同的研究中,骨密度值有所增加、降低或保持正常。本研究除腰椎(L1-4)T分数外,得到了类似的结果。

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