糖尿病绝经后女性中骨质疏松症的患病率。

Prevalence of osteoporosis among postmenopausal females with diabetes mellitus.

作者信息

Al-Maatouq Mohamed A, El-Desouki Mahmoud I, Othman Saleh A, Mattar Essam H, Babay Zainab A, Addar Mohammed

机构信息

Department of Endocrinology, King Khalid University Hospital, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2004 Oct;25(10):1423-7.

PMID:15494815

Abstract

OBJECTIVE

To assess the prevalence of osteopenia and osteoporosis among Saudi postmenopausal women with non-insulin dependent type 2 diabetes mellitus (T2DM).

METHODS

The study was carried out at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia from February 2000 to September 2002. Bone mineral density (BMD) of the lumbar spine and femoral neck using dual x-ray absorptiometry (DXA; Lunar Wisconsin), were performed in 104 postmenopausal Saudi women with T2DM, and 101 postmenopausal non-diabetic women (control). Bone mineral density was measured in gm/cm2 and both T-score and Z-score were measured but only T-score was used for analysis based on World Health Organization criteria. Bone profile, 25(OH) Vitamin D, 1,25(OH)2 Vitamin D, parathyroid hormone and urine deoxypyridinoline (DPD) were measured in most patients and controls. Body fat measurement around the biceps muscles using Futrex (body composition analyzer) were performed in patients and controls. Years postmenopausal, duration of diabetes mellitus, parity, exercise, sun exposure and milk consumption were also recorded.

RESULTS

In the diabetic group, the mean spine BMD was 0.928 gm/cm2 (T-score = -2.28 SD) and for femoral neck the mean BMD was 0.817 gm/cm2 (T-score = -1.21 SD). In control group, the mean spine BMD was 1.036 gm/cm2 (T-score = -1.2) and mean femoral neck BMD was 0.914 gm/cm2 (T-score = -0.608). In the diabetic group, there was 16 (16.64%) patients with normal BMD of the spine, 42 patients (43.68%) with osteopenia (mean T-score = -1.8 SD) and 45 (46.8%) with osteoporosis (mean T-score = -3.3 SD).

CONCLUSION

Osteoporosis is more common among Type 2 postmenopausal females in this ethnic group. Since both groups are postmenopausal, having equal percentage of Vitamin D deficiency, multi-parity, non exposure to sun, lack of exercise and negligible milk intake, one can conclude that the low BMD can be attributed to DM in the absence of other causes of osteoporosis.

摘要

目的

评估沙特绝经后非胰岛素依赖型2型糖尿病（T2DM）女性中骨质减少和骨质疏松的患病率。

方法

该研究于2000年2月至2002年9月在沙特阿拉伯王国利雅得的哈立德国王大学医院进行。对104名绝经后沙特T2DM女性和101名绝经后非糖尿病女性（对照组）使用双能X线吸收法（DXA；Lunar Wisconsin）测量腰椎和股骨颈的骨密度（BMD）。骨密度以克/平方厘米为单位进行测量，同时测量T值和Z值，但根据世界卫生组织标准，仅使用T值进行分析。对大多数患者和对照组测量了骨代谢指标、25（OH）维生素D、1,25（OH）₂维生素D、甲状旁腺激素和尿脱氧吡啶啉（DPD）。使用Futrex（身体成分分析仪）对患者和对照组进行肱二头肌周围的体脂测量。还记录了绝经后的年限、糖尿病病程、产次、运动、日照情况和牛奶摄入量。

结果

糖尿病组中，腰椎平均骨密度为0.928克/平方厘米（T值=-2.28标准差），股骨颈平均骨密度为0.817克/平方厘米（T值=-1.21标准差）。对照组中，腰椎平均骨密度为1.036克/平方厘米（T值=-1.2），股骨颈平均骨密度为0.914克/平方厘米（T值=-0.608）。糖尿病组中，16名（16.64%）患者腰椎骨密度正常，42名患者（43.68%）骨质减少（平均T值=-1.8标准差），45名（46.8%）患者骨质疏松（平均T值=-3.3标准差）。