Taylor G S, Bywater R A
Department of Physiology, Monash University, Clayton, Victoria, Australia.
Pharmacol Ther. 1989;40(3):401-38. doi: 10.1016/0163-7258(89)90087-9.
A wide variety of substances, including amines and peptides, have been detected within the complex neuronal pathways of the enteric nervous system using immunohistochemical techniques. In this article we have discussed some of the more recent data on the effects of these substances on intestinal activity. We have also commented on the many difficulties associated with ascribing neurotransmitter status to individual compounds. The technique of immunoblockade of neurogenic functional responses has been used in an attempt to identify some of the putative neurotransmitter substances. The search for selective antagonists continues.
利用免疫组织化学技术，在肠神经系统复杂的神经通路中已检测到多种物质，包括胺类和肽类。在本文中，我们讨论了这些物质对肠道活动影响的一些最新数据。我们还评论了将神经递质状态归因于个别化合物所涉及的诸多困难。神经源性功能反应的免疫阻断技术已被用于试图识别一些假定的神经递质物质。对选择性拮抗剂的寻找仍在继续。
