Rouillé Y, Michel G, Chauvet M T, Chauvet J, Acher R
Laboratory of Biological Chemistry, University of Paris VI, France.
FEBS Lett. 1989 Mar 13;245(1-2):215-8. doi: 10.1016/0014-5793(89)80224-8.
alpha- and beta-melanocyte-stimulating hormones (alpha-MSH and beta-MSH) have been isolated from Xenopus laevis neurointermediate pituitary and microsequenced. Intracellular alpha-MSH is not N-acetylated after proteolytic processing of pro-opiomelanocortin in contrast to mammalian alpha-MSHs. There is a high preservation of the melanotropic amino acid sequence common to all MSHs although in Xenopus beta-MSH a histidine residue replaces the glutamic acid residue found in position 8 of mammalian beta-MSHs.
